Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall.
Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall.
复制标题
结核病药物开发中的分子参与者：细胞壁的另一个突破。
DOI：
10.2174/0929867324666170208150016
复制
发表时间：
2017
影响因子：
4.1
通讯作者：
R. Berisio
中科院分区：
文献类型：
--
作者：
F. Squeglia;M. Romano;A. Ruggiero;R. Berisio
结核病是主要杀手，尤其是对艾滋病毒感染者而言。应对这种疾病是一项真正的医疗需要，由于多重耐药和广泛耐药菌株的日益蔓延，这种疾病难以治疗。对几乎所有现有药物都具有耐药性的结核病病例正在世界各地以惊人的速度增加。在这里，我们回顾了目前在抗结核药物开发领域的知识，重点是药物的作用机制和所涉及的靶向细菌细胞过程。特别强调的是致力于细胞壁合成的过程，这已被证明为药物开发提供了强大的潜力。希望对关键分子机制的深入了解将为我们更好地勾勒出可能的抗菌作用机制，并为未来设计更有效的治疗耐药结核病的策略提供线索。
Tuberculosis is a leading killer, especially for people living with HIV. It is a real medical need to tackle this disease, which is made difficult to treat due to the increasing spread of multi-drug-resistant and extensively drug-resistant bacterial strains. Cases of tuberculosis that are resistant to virtually all drugs currently available are increasing at an alarming rate around the world. Here, we review the current knowledge in the field of drug development against tuberculosis with a focus on the mechanisms of action of drugs and the targeted bacterial cell processes involved. Particular emphasis is dedicated to the process of cell wall synthesis, which has proven to provide strong potentialities for drug development. It is hoped that a deeper understanding of key molecular machineries to tackle will provide us with a better outline of possible antibacterial mechanisms of action and offer hints for the design of more efficient strategies to treat resistant tuberculosis in the future.