BENZENE AND LEUKEMIA - AN EPIDEMIOLOGIC RISK ASSESSMENT
BENZENE AND LEUKEMIA - AN EPIDEMIOLOGIC RISK ASSESSMENT
复制标题
DOI：
10.1056/nejm198704233161702
复制
发表时间：
1987-04-23
影响因子：
158.5
通讯作者：
LANDRIGAN, PJ
中科院分区：
文献类型：
--
作者：
RINSKY, RA;SMITH, AB;LANDRIGAN, PJ
为了定量评估苯暴露与白血病之间的关系，我们研究了一个职业性苯暴露队列的死亡率。每个群组成员的累积接触量是根据历史空气采样数据估算的，如果没有采样数据，则根据现有数据进行插值。白血病的总体标准化死亡率比（相对风险乘以100）为337（95%置信区间，154至641），多发性骨髓瘤为409（95%置信区间，110至1047）。根据累积暴露水平分层，白血病的标准化死亡率分别从109增加到322，1186和6637，累积苯暴露量从小于40 ppm-年增加到40至199，200至399和400或更多。400 ppm-年的累积苯暴露量相当于40年工作寿命中平均每年10 ppm的暴露量; 10 ppm是美国目前可执行的苯职业暴露标准。为了检查确认-应答关系的形状，我们进行了条件逻辑回归分析，其中10名对照与每个白血病队列成员相匹配。根据这一模型，可以计算出，对苯诱导白血病的保护将随着允许接触限值的任何降低而呈指数级增加。
To assess quantitatively the association between benzene exposure and leukemia, we examined the mortality rate of a cohort with occupational exposure to benzene. Cumulative exposure for each cohort member was estimated from historical air-sampling data and, when no sampling data existed, from interpolation on the basis of existing data. The overall standardized mortality ratio (a measure of relative risk multiplied by 100) for leukemia was 337 (95 percent confidence interval, 154 to 641), and that for multiple myeloma was 409 (95 percent confidence interval, 110 to 1047). With stratification according to levels of cumulative exposure, the standardized mortality ratios for leukemia increased from 109 to 322, 1186, and 6637 with increases in cumulative benzene exposure from less than 40 parts per million-years (ppm-years), to 40 to 199, 200 to 399, and 400 or more, respectively. A cumulative benzene exposure of 400 ppm-years is equivalent to a mean annual exposure of 10 ppm over a 40-year working lifetime; 10 ppm is the currently enforceable standard in the United States for occupational exposure to benzene. To examine the shape of the exposure-response relation, we performed a conditional logistic-regression analysis, in which 10 controls were matched to each cohort member with leukemia. From this model, it can be calculated that protection from benzene-induced leukemia would increase exponentially with any reduction in the permissible exposure limit.