A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China
A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China
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DOI：
10.1111/j.1398-9995.2009.01967.x
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发表时间：
2009-07-01
期刊：
影响因子：
12.4
通讯作者：
Zhong, N.
中科院分区：
文献类型：
--
作者：
Li, J.;Sun, B.;Zhong, N.
中国大陆哮喘和鼻炎患者的过敏患病率仍不清楚。我们的目的是估计中国大陆呼吸系统诊所就诊的哮喘和/或鼻炎等呼吸道过敏性疾病患者的过敏患病率。该研究还调查了中国患者的患病率和过敏模式的地区和年度差异。对中国4个地区17个城市的6304名哮喘和/或鼻炎患者进行了横断面调查。患者填写标准化问卷，询问是否存在呼吸道和过敏症状。他们还接受了 13 种常见空气过敏原的皮肤点刺测试。在 6304 名患者中，4545 名（72.1%）至少有一种皮肤点刺反应呈阳性。皮肤点刺反应阳性的总发生率为：粉尘螨为59.0%，屋尘螨为57.6%，热带小蠊为40.7%，美洲大蠊为16.1%，狗为14.0%，德国小蠊为11.5%，艾蒿为11.3%，艾蒿为10.3%对于猫，豚草为 6.5%，混合霉菌 I 为 6.3%，混合霉菌 IV 为 4.4%，混合草花粉为 3.5%，混合树花粉为 2.2%。不同地理区域对常见过敏原的敏感性差异很大，并且通过按年龄组、哮喘和/或鼻炎患者分层，表现出独特的模式。鼻炎和哮喘的严重程度分别与皮肤对艾蒿、豚草以及对屋尘螨、粉尘螨和热带布洛米亚的反应指数显着相关（P < 0.001）。在哮喘和鼻炎患者中，对测试的过敏原的阳性反应性以及对多种过敏原（包括屋尘螨和热带布洛米亚）的伴随反应性显着增加。屋尘螨是中国哮喘和/或鼻炎患者中最常见的过敏原。来自不同地理区域、年龄组以及哮喘和/或鼻炎的患者的过敏模式存在显着差异。
The prevalence of sensitization in patients with asthma and rhinitis in mainland China remains unclear.Our aim was to estimate the prevalence of allergy in patients with respiratory allergic diseases such as asthma and/or rhinitis attending respiratory clinics within mainland China. The study also investigated regional and annual differences in the prevalence and pattern of sensitization among the patients in China.A cross-sectional survey was performed in 6304 patients suffering from asthma and/or rhinitis in 17 cities from 4 regions of China. Patients completed a standardized questionnaire asking for the presence of respiratory and allergic symptoms. They also underwent skin prick tests with 13 common aeroallergens.Among the 6304 patients, 4545 (72.1%) had at least one positive skin prick reaction. The overall prevalence of positive skin prick responses was 59.0% for Dermatophagoides farinae, 57.6% for Dermatophagoides pteronyssinus, 40.7% for Blomia tropicalis, 16.1% for American cockroach, 14.0% for dog, 11.5% for Blatella germanica, 11.3% for Artemisia vulgaris, 10.3% for cat, 6.5% for Ambrosia artemisifolia, 6.3% for mixed mould I, 4.4% for mixed mould IV, 3.5% for mixed grass pollen and 2.2% for mixed tree pollen. Sensitizations to common allergens varied widely between geographical areas and demonstrated unique pattern in patients by stratification with age groups, with asthma and/or rhinitis. Severity of rhinitis and asthma was significantly correlated with skin index of reactivity to Artemisia vulgaris, Ambrosia artemisifolia and to D. pteronyssinus, D. farinae and Blomia tropicalis respectively (P < 0.001). Positive reactivity to the tested allergens and concomitant reactivity to multiple allergens including to house dust mites and Blomia tropicalis was markedly increased in patients with both asthma and rhinitis.House dust mites were the most prevalent allergens in patients with asthma and/or rhinitis in China. There were significant differences in patterns of sensitizations in patients from different geographical areas, age groups as well as asthma and/or rhinitis.