Population differences in proinflammatory biology: Japanese have healthier profiles than Americans
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans
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DOI：
10.1016/j.bbi.2010.11.013
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发表时间：
2011-03-01
影响因子：
15.1
通讯作者：
Ryff, Carol D.
中科院分区：
文献类型：
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作者：
Coe, Christopher L.;Love, Gayle D.;Ryff, Carol D.
多效性细胞因子，白细胞介素-6 (IL-6)，已经成为衰老生物学和炎症生理学的关键因素。然而，我们对IL-6正常功能的了解主要来自对欧洲人群和欧洲裔美国人的研究。我们的分析比较了382名中老年日本人和1209名来自美国中年调查（MIDUS）的白种人和非裔美国人的IL-6水平。从30岁到80岁，日本人的平均IL-6水平明显较低。c反应蛋白（CRP）和纤维蛋白原（FBG）水平的显著降低为促炎活性的人群差异提供了确凿证据。由于IL-6的释放与肥胖有关，因此考虑了体重指数（BMI）的差异。日本人的总体BMI最低，非裔美国人的总体BMI最高，但即使在将BMI作为协变量纳入分析后，IL-6的显著组间差异仍然存在。当对IL-6可溶性受体（sIL-6r）的系统水平进行评估时，进一步支持了IL-6生物学的明显变化。日本人血清sIL-6r高于美国人，但非裔美国人的il -6r明显较低。我们的细胞因子数据与与炎症生理相关的年龄相关疾病（包括心血管疾病）患病率的国家差异一致。研究结果还强调了扩大健康和老龄化人口研究中包括的人群多样性的重要性，特别是考虑到一些亚洲国家和生活在美国的亚洲血统个体的信息相对缺乏。(C) 2010爱思唯尔公司版权所有。
The pleiotropic cytokine, interleukin-6 (IL-6), has emerged as a key factor in the biology of aging and the physiology of inflammation. Yet much of what we know about the normal functioning of IL-6 has been generated primarily from research on European populations and Americans of European descent. Our analyses compared IL-6 levels in 382 middle-aged and older Japanese to the values found in 1209 Caucasian- and African-Americans from the Midlife in the United States survey (MIDUS). Across the life span from 30 to 80 years of age, mean IL-6 levels were strikingly lower in Japanese individuals. Significantly lower levels of C-reactive protein (CRP) and fibrinogen (FBG) provided confirmatory evidence for a population difference in proinflammatory activity. Because IL-6 release has been associated with obesity, differences in body mass index (BMI) were taken into consideration. Japanese had the lowest, and African-Americans had the highest overall BMIs, but significant group differences in IL-6 persisted even after BMI was included as a covariate in the analyses. Additional support for distinct variation in IL-6 biology was generated when systemic levels of the soluble receptor for IL-6 (sIL-6r) were evaluated. Serum sIL-6r was higher in Japanese than Americans, but was most notably low in African-Americans. Our cytokine data concur with national differences in the prevalence of age-related illnesses linked to inflammatory physiology, including cardiovascular disease. The findings also highlight the importance of broadening the diversity of people included in population studies of health and aging, especially given the relative paucity of information for some Asian countries and on individuals of Asian heritage living in the US. (C) 2010 Elsevier Inc. All rights reserved.