Evaluation of TDM System for Setting of Initial Anti-MRSA Drug Dosages by Pharmacists at Two Hospitals
Evaluation of TDM System for Setting of Initial Anti-MRSA Drug Dosages by Pharmacists at Two Hospitals
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两家医院药剂师设定初始抗 MRSA 药物剂量的 TDM 系统评估
DOI：
10.5649/jjphcs.32.985
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
T. Tsuchiya
中科院分区：
文献类型：
--
作者：
H. Teramachi;M. Yasuda;M. Okada;E. Takashima;Masafumi Kubota;Y. Imai;T. Tsuchiya
在中野高生医院，药师通过设定万古霉素（VCM）初始剂量，优化VCM抗甲氧西林耐药金黄色葡萄球菌（MRSA）的峰谷浓度，显著缩短了VCM治疗的平均持续时间，预防了肾功能损害，取得了较高的临床疗效和治疗经济性。鉴于此，我们开发了一套初始剂量设定系统，称为“药剂师设定抗mrsa药物初始剂量TDM系统”。我们还向医生和护士介绍了该系统和TDM的基本知识，并编写了TDM手册。因此，在Chu-no Kosei医院，药剂师达到VCM目标浓度的比率和VCM初始剂量的设定显着提高。可预防肾功能不全，临床疗效高。我们的系统还使西野高成医院（Nishimino Kosei hospital）的所有抗mrsa药物都能进行TDM，该医院以前没有进行TDM，它产生了与chuno Kosei医院相同的临床和经济效益。我们引进该系统的经验表明，积极告知医生和护士关于它的使用和TDM是非常必要的。
In Chu-no Kosei hospital, the setting of the initial dosage of vancomycin (VCM) by pharmacists to optimize trough and peak VCM concentrations against methicillin-resistant Staphylococcus aureus (MRSA) significantly reduced the mean duration of VCM therapy, prevented renal dysfunction, and achieved high clinical efficacy and economy in treatment.In view of this, we developed a system for setting initial dosages called “TDM system for the setting of initial anti-MRSA drug dosages by pharmacists”. We also informed doctors and nurses about the basics of the system and TDM and created a TDM manual. As a result, in Chu-no Kosei hospital, the rates for attaining target VCM concentrations, and setting of initial VCM dosage by pharmacists rose significantly. In addition renal dysfunction could be prevented and high clinical efficacy achieved. Our system also enabled TDM to be conducted for all anti-MRSA drugs at Nishimino Kosei hospital, where TDM had previously not been practiced, and it produced the same clinical and economic benefits as at Chu-no Kosei Hospital. Our experience of introducing the system showed that it was very necessary to actively inform doctors and nurses concerning its use and TDM.