Cortical excitability and plasticity in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of transcranial magnetic stimulation studies.
Cortical excitability and plasticity in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of transcranial magnetic stimulation studies.
复制标题
DOI：
10.1016/j.arr.2022.101660
复制
发表时间：
2022-08
影响因子：
13.1
通讯作者：
中科院分区：
文献类型：
--
作者：
经颅磁刺激(TMS)是一种非侵入性神经调节技术。当对初级运动皮质施加刺激并结合肌电测量时，TMS可以在体内探索皮质的兴奋性和可塑性的功能。这项荟萃分析的目的是评估TMS衍生的测量方法在区分阿尔茨海默病(AD)和轻度认知障碍(MCI)患者与认知正常老年人(CN)方面的有效性。搜索的数据库包括PubMed、Embase、APA QicINFO、Medline和CINAHL Plus，从最初到2021年7月。共有2,728名参与者(1,454名AD患者、163名MCI患者和1,111名CN患者)参加了61项研究。AD患者的皮质兴奋性显著高于CN组，皮质抑制明显低于CN组，皮质可塑性受损。与CN队列相比，MCI患者表现出皮质兴奋性增强和可塑性降低。此外，较低的认知表现与较高的大脑皮层兴奋性和较低的抑制力显著相关。没有TMS引起的癫痫事件的报道，轻度不良反应发生率约为3/1000(即9/2728)。我们的荟萃分析结果表明，使用TMS来源的皮质兴奋性和可塑性指标作为AD和MCI的诊断生物标记物和治疗靶点的潜力。
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique. When stimulation is applied over the primary motor cortex and coupled with electromyography measures, TMS can probe functions of cortical excitability and plasticity in vivo. The purpose of this meta-analysis is to evaluate the utility of TMS-derived measures for differentiating patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) from cognitively normal older adults (CN). Databases searched included PubMed, Embase, APA PsycInfo, Medline, and CINAHL Plus from inception to July 2021. Sixty-one studies with a total of 2,728 participants (1,454 patients with AD, 163 patients with MCI, and 1,111 CN) were included. Patients with AD showed significantly higher cortical excitability, lower cortical inhibition, and impaired cortical plasticity compared to the CN cohorts. Patients with MCI exhibited increased cortical excitability and reduced plasticity compared to the CN cohort. Additionally, lower cognitive performance was significantly associated with higher cortical excitability and lower inhibition. No seizure events due to TMS were reported, and the mild adverse response rate is approximately 3/1000 (i.e., 9/2728). Findings of our meta-analysis demonstrate the potential of using TMS-derived cortical excitability and plasticity measures as diagnostic biomarkers and therapeutic targets for AD and MCI.
登录
查看更多内容
影响因子：
4.2
作者：
Buss SS;Press DZ;McDonald K;Kitchener E;O'Connor M;Donohoe K;Shafi MM;Pascual-Leone A;Fried PJ
通讯作者：
Fried PJ
影响因子：
5.3
作者：
Cheng, Aiwu;Wang, Jing;Mattson, Mark P.
通讯作者：
Mattson, Mark P.
影响因子：
9
作者：
Benussi, Alberto;Alberici, Antonella;Borroni, Barbara
通讯作者：
Borroni, Barbara
影响因子：
3.8
作者：
Beamer, Edward;Conte, Giorgia;Engel, Tobias
通讯作者：
Engel, Tobias
影响因子：
4
作者：
Bonni, Sonia;Lupo, Federica;Koch, Giacomo
通讯作者：
Koch, Giacomo