A Novel Collagen Dot Assay for Monitoring Cancer Cell Migration
A Novel Collagen Dot Assay for Monitoring Cancer Cell Migration
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DOI：
10.1007/978-1-4939-3444-7_15
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Cao, Jian
中科院分区：
文献类型：
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作者：
Alford, Vincent M.;Roth, Eric;Cao, Jian
细胞迁移是癌症侵袭和转移的关键决定因素。由于缺乏有效的检测方法来监测癌细胞迁移，靶向癌细胞迁移的药物受到阻碍。在这里，我们描述了一种新的方法，显微镜监测细胞迁移的定量方式。该检测可用于研究参与癌细胞迁移的基因，以及筛选靶向该细胞过程的抗癌药物。
Cell migration is a critical determinant of cancer invasion and metastasis. Drugs targeting cancer cell migration have been hindered due to the lack of effective assays for monitoring cancer cell migration. Here we describe a novel method to microscopically monitor cell migration in a quantitative fashion. This assay can be used to study genes involved in cancer cell migration, as well as screening anticancer drugs that target this cellular process.