Practical lessons from protein structure prediction.

Practical lessons from protein structure prediction.
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蛋白质结构预测的实践经验教训。

DOI:
10.1093/nar/gki327
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发表时间:
2005
影响因子:
14.9
通讯作者:
Rychlewski, L
Rychlewski, L
中科院分区:
生物学2区
文献类型:
--
作者:
Ginalski, K;Grishin, NV;Godzik, A;Rychlewski, L

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尽管最近努力开发自动化蛋白质结构测定方案,结构基因组学项目在产生完整蛋白质组的折叠分配方面进展缓慢,并且许多蛋白质家族的空间结构仍然未知。使用预测算法来分配折叠的替代廉价和快速的方法继续为许多蛋白质提供有价值的结构信息。在过去几年里,通过在全社区范围内进行客观评估实验,高质量预测方法的发展得到了推动。本文概述了目前可用的实用方法,能够产生准确的折叠分配的蛋白质结构预测。最后讨论了预测质量评估的最新进展。
Despite recent efforts to develop automated protein structure determination protocols, structural genomics projects are slow in generating fold assignments for complete proteomes, and spatial structures remain unknown for many protein families. Alternative cheap and fast methods to assign folds using prediction algorithms continue to provide valuable structural information for many proteins. The development of high-quality prediction methods has been boosted in the last years by objective community-wide assessment experiments. This paper gives an overview of the currently available practical approaches to protein structure prediction capable of generating accurate fold assignment. Recent advances in assessment of the prediction quality are also discussed.
DOI: 10.1016/s1093-3263(00)00138-8
发表时间: 2001-01-01
影响因子: 2.9
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