POLYOL ACCUMULATION IN GALACTOSEMIC AND DIABETIC RATS - CONTROL BY AN ALDOSE REDUCTASE INHIBITOR
POLYOL ACCUMULATION IN GALACTOSEMIC AND DIABETIC RATS - CONTROL BY AN ALDOSE REDUCTASE INHIBITOR
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DOI：
10.1126/science.182.4117.1146
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发表时间：
1973-01-01
期刊：
影响因子：
56.9
通讯作者：
MEROLA, LO
中科院分区：
文献类型：
--
作者：
DVORNIK, D;SIMARDDU.N;MEROLA, LO
口服活性醛糖还原酶抑制剂1，3-二氧代-1H-苯并[de]异喹啉-2（3 H）乙酸（AY-22，284）可预防暴露于高浓度半乳糖的培养晶状体的白内障变化。口服AY-22，284可显著降低半乳糖血症大鼠和链脲佐菌素诱导的糖尿病大鼠晶状体和坐骨神经中多元醇的积累。此外，用AY-22，284治疗半乳糖血症大鼠可有效抑制白内障的形成。
An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose. When given orally, AY-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactosemic rats with AY-22,284 effectively suppressed the formation of cataracts.