Expression of N-cadherin and -catenin in human meningioma in correlation with peritumoral edema
Expression of N-cadherin and -catenin in human meningioma in correlation with peritumoral edema
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DOI：
10.1080/00207454.2018.1424153
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发表时间：
2018-01-01
影响因子：
2.2
通讯作者：
Reszec, Joanna
中科院分区：
文献类型：
--
作者：
Rutkowski, Robert;Chrzanowski, Robert;Reszec, Joanna
目的：分析-catenin和N-cadherin在脑膜瘤中的表达，探讨其与瘤周脑水肿（PTBE）的关系。材料与方法：研究组由154例颅内脑膜瘤患者组成，分为低级别组（G1）和高级别组（G2或G3）。采用Steinhoff分类法将PTBE分为4组（0、I、II、III）。分析N-cadherin、-catenin的表达，并根据免疫反应性阳性率进行分级。结果进行统计学分析。结果：低级别脑膜瘤104例，高级别脑膜瘤50例。103例（66.8%）出现PTBE，其中ⅰ级57例，ⅱ级44例，ⅲ级2例。低级别组50例（48.1%）仅在肿瘤细胞膜上发现N-cadherin阳性表达，高级别组34例（68%）。在低级别脑膜瘤中，54例（51.9%）在细胞质和细胞核内观察到-catenin表达。在高级别脑膜瘤中，33例（66%）肿瘤仅在细胞核内表达-catenin。PTBE I级36例，II级28例，III级2例均有N-cadherin表达。-catenin在PTBE I级40例，II级24例，III级2例中表达。结果具有统计学意义。结论：N-cadherin在高级别脑膜瘤组中表达显著。-catenin在细胞核中表达最明显，细胞质中表达最明显。PTBE的程度与N-cadherin和-catenin的表达相关，在高级别脑膜瘤组中表现最为突出。
Objective: To analyze the expression of -catenin and N-cadherin in large series of meningioma cases and to investigate their correlation with peritumoral brain edema (PTBE). Materials and methods: Study group consists of 154 patients diagnosed with intracranial meningioma divided into: low-grade (G1) and high-grade (G2 or G3) group. PTBE was graded into four groups (0, I, II, III) using Steinhoff classification. The expression of N-cadherin, -catenin was analyzed and graded based on the positive ratio of immunoreactivity. The results were analyzed statistically. Results: 104 cases were low-grade and 50 high-grade meningiomas. PTBE was observed in 103(66.8 %) cases: 57 grade I, 44 grade II and 2 grade III. Positive N-cadherin expression was found only in the membrane of the neoplastic cells in 50(48.1%) cases of low-grade, and in 34(68%) of high-grade group. In low-grade meningioma, -catenin expression was observed within the cytoplasm and nucleus in 54(51.9%) cases. In high-grade meningiomas, -catenin expression was observed in 33(66%) tumors only within the nucleus. N-cadherin expression was observed in 36 cases with PTBE grade I, 28 with grade II and 2 with grade III. -catenin expression was observed in 40 cases with PTBE grade I, 24 with grade II and 2 with grade III. The results were statistically significant. Conclusions: Significant N-cadherin expression especially in high-grade meningioma group was found. -catenin expression was the most evident in the nucleus rather than in cytoplasm. The degree of PTBE correlated with the N-cadherin and -catenin expression and was the most prominent in high-grade meningioma group.