Dualism of gene GC content and CpG pattern in regard to expression in the human genome: magnitude versus breadth
Dualism of gene GC content and CpG pattern in regard to expression in the human genome: magnitude versus breadth
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DOI：
10.1016/j.tig.2005.09.002
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发表时间：
2005-12-01
影响因子：
11.4
通讯作者：
Vinogradov, AE
中科院分区：
文献类型：
--
作者：
Vinogradov, AE
在这篇文章中，我表明，在人类基因组中，GC含量的基因（而不是启动子中的CpG岛）与组织之间的基因表达的最大水平，而启动子CpG岛和基因CpG水平更强烈地与组织之间的表达的广度。基因GC含量与表达的相关性不可能是转录的结果（即副产物），因为它与种系中的表达不相关。GC含量和CpG水平的变化可以决定基因表达的特征，与转录因子结合位点（由染色质凝聚介导）协同作用。
In this article, I show that, in the human genome, the GC content in genes (but not the CpG island in the promoter) is related to the maximum level of gene expression among tissues, whereas the promoter CpG island and gene CpG level are more strongly related to the breadth of expression among tissues. The relevance of gene GC content to expression cannot be a consequence (i.e. a byproduct) of transcription because it does not correlate with expression in the germline. The variation of GC content and CpG level can determine the characteristics of gene expression in a synergistic interplay with transcription-factor-binding sites (mediated by chromatin condensation).