What Is the Role of Serological Markers in IBD? Pediatric and Adult Data
What Is the Role of Serological Markers in IBD? Pediatric and Adult Data
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DOI：
10.1159/000228559
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发表时间：
2009-01-01
影响因子：
2.3
通讯作者：
Dubinsky, Marla
中科院分区：
文献类型：
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作者：
Dubinsky, Marla
医生在很大程度上依赖疾病标志物的存在来支持甚至有时改变他们对某些只能在临床上诊断的疾病的临床印象。通常，这些标记物在帮助建立诊断和评估随时间推移的慢性病活动性方面发挥着重要作用。然而，炎症性肠病(IBD)的诊断并不完全基于临床理由。为了做出正确的诊断和区分疾病亚型，需要满足侵袭性内窥镜和放射学以及组织病理学的标准。寻找新的诊断方法，准确区分一组IBD患者和那些未受该疾病影响的患者，已成为IBD研究的重点。然而，这项研究在寻找生物和遗传标记方面取得了非常令人兴奋的转折，这些标记可以评估自然历史并预测个人疾病的过程，包括随着时间的推移对治疗的反应。版权所有(C)2009 S.Karger AG，巴塞尔
Physicians rely heavily on the presence of disease markers to support or even at times modify their clinical impression for certain diseases that can only be diagnosed clinically. Typically these markers play an important role in helping to establish a diagnosis and to evaluate the activity of a chronic disease over time. The diagnosis of inflammatory bowel disease (IBD), however, is not based solely on clinical grounds. Invasive endoscopic and radiological as well as histopathological criteria need to be met in order to make a correct diagnosis and differentiate disease subtypes. The search for novel diagnostic approaches that accurately distinguishes a group of patients with IBD from those unaffected by the disease has become a focus in IBD research. This search, however, has taken a very exciting turn in the direction of finding biologic and genetic markers that can assess the natural history and predict the course of individual's disease including response to treatments over time. Copyright (C) 2009 S. Karger AG, Basel