Circulating Endothelial Progenitor Cells and Age-Related White Matter Changes
Circulating Endothelial Progenitor Cells and Age-Related White Matter Changes
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DOI：
10.1161/strokeaha.109.554527
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发表时间：
2009-10-01
期刊：
影响因子：
8.3
通讯作者：
Camicioli, Richard
中科院分区：
文献类型：
--
作者：
Jickling, Glen;Salam, Abdul;Camicioli, Richard
背景和目的：本研究的目的是评估循环内皮祖细胞（EPC）和年龄相关性白色物质改变（ARWMC）之间的关系。内皮功能障碍在ARWMC的发展中起作用。EPC参与血管内皮损伤的修复，并参与血管危险因素诱导的内皮损伤的修复。ARWMC可以使用CT或MRI进行评估。方法，在172个人，循环EPC定义的表面标志物CD 31和血管性血友病因子。使用ARWMC量表在CT扫描上对ARWMC进行评级，并根据ARWMC量表评分分为3组（ARWMC评分0 [无]，评分1-10 [轻度至中度]，评分> 10 [重度]）。ARWMC的严重程度与EPC水平和血管危险因素有关。结果在单因素分析中，发现严重ARWMC患者的EPC水平显著降低（P = 0.01）。ARWMC还与高血压（P < 0.001）、年龄（P < 0.001）、肌酐清除率（P = 0.031）、C反应蛋白（P < 0.001）和血管紧张素转换酶或血管紧张素受体阻滞剂的使用（P = 0.004）有关。多元Logistic回归分析确定EPC水平，年龄，高血压，高血脂症严重ARWMC. Conclusions循环EPC水平显着较低的严重ARWMC患者的显着独立的预测因子。与严重ARWMC显著相关的其他变量是年龄、高血压和高甘油三酯血症。需要进一步的研究来描述EPC、血管危险因素和ARWMC之间的病理生理学关系。（中风。2009;40：3191-3196）。
Background and Purpose-The objective was to evaluate the relationship between circulating endothelial progenitor cells (EPC) and age-related white matter changes (ARWMC). Endothelial dysfunction plays a role in the development of ARWMC. EPC incorporate into sites endothelial damage and are thought to be involved in the repair of vascular risk factor induced endothelial injury. ARWMC can be evaluated using CT or MRI.Methods-In 172 individuals, circulating EPC were defined by the surface markers CD31 and von Willebrand factor. ARWMC were rated on CT scan using the ARWMC scale and divided into 3 groups based on ARWMC scale score (ARWMC score 0 [none], score 1-10 [mild-to-moderate], score > 10 [severe]). Severity of ARWMC was correlated with levels of EPC and vascular risk factors.Results-On univariate analysis, EPC were found to be significantly lower in patients with severe ARWMC (P = 0.01). ARWMC were also associated with hypertension (P < 0.001), age (P < 0.001), creatinine clearance (P = 0.031), C-reactive protein (P < 0.001), and use of angiotensin-converting enzyme or angiotensin receptor blocker (P = 0.004). Multiple logistic regression analysis identified EPC level, age, hypertension, and hypertriglyceridemia as significant independent predictors of severe ARWMC.Conclusions-Levels of circulating EPC were significantly lower in patients with severe ARWMC. Other variables significantly associated with severe ARWMC were age, hypertension, and hypertriglyceridemia. Further study is required to delineate the pathophysiological relationship between EPC, vascular risk factors, and ARWMC. (Stroke. 2009;40:3191-3196.)