Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
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瑞士乳杆菌-MIKI-020 增强小鼠睡眠期间肝脏 FGF21 表达并降低核心体温
DOI：
10.1016/j.jff.2019.01.012
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发表时间：
2019
影响因子：
5.6
通讯作者：
Kawada Teruo
中科院分区：
文献类型：
--
作者：
Kiriyama Kohei;Goto Tsuyoshi;Yamamoto Hirotaka;Ara Takeshi;Takahashi Haruya;Jheng Huei-Fen;Nomura Wataru;Inoue Hiroyasu;Nakata Rieko;Kawada Teruo
据报道，睡眠的开始伴随着夜间开始时核心体温（CBT）的下降。通过PPARα激动剂刺激肝FGF 21影响中枢神经系统并降低CBT。本研究旨在使用瑞士乳杆菌-MIKI-020（LH）评价食源性PPARα激活剂对肝脏FGF 21表达和CBT调节的影响。LH处理以PPARα依赖性方式刺激肝细胞中FGF 21的表达。此外，两周的LH治疗仅在小鼠睡眠期间降低了CBT。LH组肝脏中FGF 21的表达和血浆中FGF 21的含量均显著高于对照组。研究结果提出了一种新的方法来减少睡眠期间的CBT，这可能会改善睡眠障碍。
The onset of sleep has been reported to be accompanied by a decline in the core body temperature (CBT) at the onset of night. The stimulation of hepatic FGF21 by PPARα agonist influences the central nervous system and decreases the CBT. The present study aimed to evaluate the effect of food-derived PPARα activator on hepatic FGF21 expression and CBT regulation using Lactobacillus helveticus-MIKI-020 (LH). The treatment with LH stimulated FGF21 expression in a PPARα-dependent manner in hepatocytes. Furthermore, two weeks of LH treatment decreased the CBT only during sleep in mice. The expression of FGF21 in the liver and the plasma content of FGF21 were significantly higher in the LH feeding group than in the control group. The results present a novel approach to decrease the CBT during sleep, which can potentially improve sleep disorders.