Biomimetic tissue-engineered anterior cruciate ligament replacement
Biomimetic tissue-engineered anterior cruciate ligament replacement
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DOI：
10.1073/pnas.0608837104
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发表时间：
2007-02-27
影响因子：
11.1
通讯作者：
Laurencin, Cato T.
中科院分区：
文献类型：
--
作者：
Cooper, James A., Jr.;Sahota, Janmeet S.;Laurencin, Cato T.
在美国，每年有超过 200,000 例前交叉韧带 (ACL) 断裂，由于 ACL 的愈合性能较差，目前治疗这些损伤的方法是使用自体移植或同种异体移植组织进行手术重建。为了再生 ACL，理想的基质应该是可生物降解的、多孔的，并且具有足够的机械强度以允许新韧带组织的形成。研究人员开发了含有胶原纤维、丝绸、可生物降解聚合物和复合材料的 ACL 支架，但取得的成功有限。我们课题组利用3D编织技术开发了仿生韧带替代品。在这项用于 ACL 重建的初步体内兔模型研究中，组织学和力学评估表明，我们的细胞接种、组织工程韧带置换具有出色的愈合和再生能力。
There are > 200,000 anterior cruciate ligament (ACL) ruptures each year in the United States, and, due to the poor healing properties of the ACL, surgical reconstruction with autograft or allograft tissue is the current treatment of these injuries. To regenerate the ACL, the ideal matrix should be biodegradable, porous, and exhibit sufficient mechanical strength to allow formation of neoligament tissue. Researchers have developed ACL scaffolds with collagen fibers, silk, biodegradable polymers, and composites with limited success. Our group has developed a biomimetic ligament replacement by using 3D braiding technology. In this preliminary in vivo rabbit model study for ACL reconstruction, the histological and mechanical evaluation demonstrated excellent healing and regeneration with our cell-seeded, tissue-engineered ligament replacement.