Nanotopological Surfaces: Microfabricated Nanotopological Surfaces for Study of Adhesion‐Dependent Cell Mechanosensitivity (Small 1/2013)
Nanotopological Surfaces: Microfabricated Nanotopological Surfaces for Study of Adhesion‐Dependent Cell Mechanosensitivity (Small 1/2013)
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DOI：
10.1002/smll.201370001
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发表时间：
2013-01
期刊：
影响因子：
13.3
通讯作者：
Weiqiang Chen;Yubing Sun;Jianping Fu
中科院分区：
文献类型：
--
作者：
Weiqiang Chen;Yubing Sun;Jianping Fu
封面显示了纳米地形表面黏附细胞的扫描电子显微镜图像。纳米级的粗糙度可以通过光刻和反应离子刻蚀的微细加工方法在玻璃表面上精确控制和空间图案化。这项技术，描述在第81页，由J.Fu和他的同事使用，以了解黏附依赖的细胞对纳米拓扑线索的机械敏感性。纳米级的拓扑特征为NIH/3T3成纤维细胞的各种行为提供了强有力的调控信号，包括细胞形态、黏附、增殖和迁移。NIH/3T3成纤维细胞的拓扑感知包括反馈调节和机械-生化整合。
The cover shows a scanning electron microscopy image of adhesive cells on a nanotopographic surface. Nanoscale roughness can be precisely controlled and spatially patterned on glass surfaces with a microfabrication method using photolithography and reactive ion etching. This technique, described on page 81, is used by J. Fu and co-workers to understand adhesion-dependent cell mechanosensitivity to nanotopological cues. Nanoscale topological features provide a potent regulatory signal over a diverse range of NIH/3T3 fibroblast behaviors, including cell morphology, adhesion, proliferation, and migration. The topological sensing of NIH/3T3 fibroblasts includes feedback regulation and mechanical-biochemical integration.