Lower serum calcium level is associated with hemorrhagic transformation after thrombolysis.
Lower serum calcium level is associated with hemorrhagic transformation after thrombolysis.
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较低的血清钙水平与溶栓后的出血转化相关
DOI：
10.1161/strokeaha.115.008992
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发表时间：
2015-05
期刊：
影响因子：
8.3
通讯作者：
Lou M
中科院分区：
文献类型：
--
作者：
Guo Y;Yan S;Zhang S;Zhang X;Chen Q;Liu K;Liebeskind DS;Lou M
我们的目的是调查入院时较低的血钙水平是否与静脉溶栓(IVT)后的出血性转化(HT)有关。根据入院时的血钙水平(Q1[<；2.16]、Q2[2.16，2.23]、Q3[2.24，2.31]、Q4[>；2.31]mmol/L)，将接受IVT治疗的患者分为四个四分位数。高血压分为出血性脑梗塞(HI)和实质出血(PH)。采用Logistic回归分析血钙水平与高血压发病率之间的关系。与第四季度相比，高血压在第一季度(OR=2.580，95%CI：[1.258，5.292]，p=0.010)、第二季度(OR=2.382，95%CI：[1.163，4.877]，p=0.018)和第三季度(OR=2.293，95%CI：[1.133，4.637]，p=0.021)更常见。与第四季度相比，Hi在第一季度(p=0.037)和第二季度(p=0.018)更常见，而PH在第一季度(p=0.029)比第四季度更常见。较低的入院血清钙水平与IVT后的高血压独立相关，这一假说需要更大的验证性试验。
We aim to investigate whether lower admission serum calcium levels are associated with hemorrhagic transformation (HT) after intravenous thrombolysis (IVT). A total of 362 patients treated with IVT was divided into four quartiles based on admission serum calcium levels (Q1[<2.16], Q2[2.16, 2.23], Q3[2.24, 2.31], Q4[>2.31] mmol/L). HT was classified as hemorrhagic infarction (HI) and parenchymal hemorrhage (PH). Logistic regression was applied to assess the association between serum calcium levels and the incidence of HT. Compared with Q4, HT was more common in Q1 (OR=2.580, 95% CI: [1.258, 5.292], p=0.010), Q2 (OR=2.382, 95% CI: [1.163, 4.877], p=0.018) and Q3 (OR=2.293, 95% CI: [1.133, 4.637], p=0.021). HI was more common in Q1 (p=0.037), and Q2 (p=0.018), compared with Q4, and PH was more common in Q1 (p=0.029) than Q4. Lower admission serum calcium level is independently associated with HT after IVT, and this hypothesis needs larger confirmatory trials.