Ontogeny of classical and operant learning behaviors in zebrafish
Ontogeny of classical and operant learning behaviors in zebrafish
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DOI：
10.1101/lm.025668.112
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发表时间：
2012-04-01
影响因子：
2
通讯作者：
Engert, Florian
中科院分区：
文献类型：
--
作者：
Valente, Andre;Huang, Kuo-Hua;Engert, Florian
发展中的斑马鱼在经典和操作性条件反射实验中的表现被测试，特别关注这些学习行为在发展过程中的出现。策略定位的视觉线索与电击配对，在两个全自动分析中用于调查这两种学习范式。这些可以在斑马鱼从幼虫到成年的整个发育过程中持续评估其行为表现。我们发现，学习能力在整个发育过程中不断提高，大约在第3周开始，并在第6周达到成人的表现水平。成年鱼很快就学会了完美的表演，而学习行为的表达显然是由视觉控制的。该记忆在成人中表现至少6小时，可恢复至少12小时。
The performance of developing zebrafish in both classical and operant conditioning assays was tested with a particular focus on the emergence of these learning behaviors during development. Strategically positioned visual cues paired with electro-shocks were used in two fully automated assays to investigate both learning paradigms. These allow the evaluation of the behavioral performance of zebrafish continuously throughout development, from larva to adult. We found that learning improves throughout development, starts reliably around week 3, and reaches adult performance levels at week 6. Adult fish quickly learned to perform perfectly, and the expression of the learned behavior is manifestly controlled by vision. The memory is behaviorally expressed in adults for at least 6 h and retrievable for at least 12 h.