Activity of adenosine deaminase in cerebrospinal fluid for the diagnosis and follow-up of tuberculous meningitis in adults.
Activity of adenosine deaminase in cerebrospinal fluid for the diagnosis and follow-up of tuberculous meningitis in adults.
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脑脊液中腺苷脱氨酶的活性用于成人结核性脑膜炎的诊断和随访。
DOI：
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发表时间：
1987
影响因子：
6.4
通讯作者：
C. Pascual
中科院分区：
文献类型：
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作者：
E. Ribera;J. Martínez;Inrna Ocaña;R. Segura;C. Pascual
我们研究了40例正常对照和205例根据疾病（结核性、病毒性和化脓性脑膜炎;肿瘤;中风和其他）分组的患者脑脊液中腺苷脱氨酶的活性。结核性脑膜炎患者的平均酶值（15.7 +/- 4.3 U/L）明显高于其他患者（1.4 +/- 1.5 U/L）。该试验诊断结核性脑膜炎的敏感性为1，特异性为0.99。对32例结核性脑膜炎患者的酶活性以及疾病进展进行了研究。在治疗的前10天内观察到酶水平显著升高，随后逐渐下降，并在治疗3至4个月后达到正常值。两名患者显示出与并发症的发展相一致的大幅增加。该试验是一种简便、可靠的结核性脑膜炎早期诊断和随访的方法。
We studied the activity of adenosine deaminase in the cerebrospinal fluid of 40 normal controls and 205 patients who were grouped according to disease (tuberculous, viral, and purulent meningitis; neoplasms; stroke; and miscellaneous). The mean enzyme value was clearly higher for the patients with tuberculous meningitis (15.7 +/- 4.3 U/liter) than for the other patients (1.4 +/- 1.5 U/liter). The sensitivity of the test for diagnosing tuberculous meningitis was 1 and specificity, 0.99. The enzyme activity, as well as progression of the disease, was studied in 32 patients with tuberculous meningitis. A significant rise in levels of enzyme was observed during the first 10 days of therapy, was followed by a gradual decline, and reached normal values after three to four months of treatment. Two patients showed substantial increases that coincided with the development of complications. The test proved to be a simple and reliable method for early diagnosis and follow-up of tuberculous meningitis.