Neutrophils: the forgotten cell in JIA disease pathogenesis.
Neutrophils: the forgotten cell in JIA disease pathogenesis.
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中性粒细胞：Jia病发病机理中被遗忘的细胞。
DOI：
10.1186/1546-0096-5-13
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发表时间：
2007-06-13
影响因子：
2.5
通讯作者：
Centola, Michael
中科院分区：
文献类型：
--
作者：
Jarvis, James N;Jiang, Kaiyu;Petty, Howard R;Centola, Michael
幼年特发性关节炎（JIA）一直被认为是一种自身免疫性疾病，由T细胞对“自身”抗原的异常识别引发。然而，系统生物学的方法，这一系列的疾病提出了复杂的先天性和适应性免疫之间的相互作用，JIA的基础。特别是，新的数据表明中性粒细胞在JIA发病机制中的重要作用。在这篇简短的综述中，我们将讨论支持中性粒细胞在JIA中发挥作用的新数据，讨论中性粒细胞与适应性免疫反应之间的调节功能，并讨论未来的研究领域。最重要的是，我们邀请读者重新考虑使用术语“自身免疫”作为适用于家庭的疾病，我们统称为JIA。
Juvenile idiopathic arthritis (JIA) has long been assumed to be an autoimmune disease, triggered by aberrant recognition of "self" antigens by T-cells. However, systems biology approaches to this family of diseases have suggested complex interactions between innate and adaptive immunity that underlie JIA. In particular, new data suggest an important role for neutrophils in JIA pathogenesis. In this short review, we will discuss the new data that support a role for neutrophils in JIA, discuss regulatory functions that link neutrophils to adaptive immune responses, and discuss future areas of investigation. Above all else, we invite the reader to re-consider the use of the term "autoimmunity" as applied to the family of illnesses we collectively call JIA.