Synthesis and Characterization of New Chlorhexidine-Containing Nanoparticles for Root Canal Disinfection.
Synthesis and Characterization of New Chlorhexidine-Containing Nanoparticles for Root Canal Disinfection.
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DOI：
10.3390/ma9060452
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Rodrigues DC
中科院分区：
文献类型：
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作者：
Haseeb R;Lau M;Sheah M;Montagner F;Quiram G;Palmer K;Stefan MC;Rodrigues DC
根管消毒是有限的，由于解剖的复杂性。需要更好的抗菌剂递送系统以确保有效的细菌根除。本研究的目的是设计一种能稳定释放药物的氯己定纳米粒。将药物洗必泰包裹在聚乙二醇-聚乳酸（PEG-b-PLA）中制备双层纳米粒。通过热重分析（TGA）确定包封效率，并且通过颗粒形态和尺寸的显微镜研究进行颗粒表征。他们的抗菌效果进行了评估超过牙髓病原菌粪肠球菌。纳米颗粒的尺寸范围为300-500 nm，这被认为足够小以渗透到小的牙本质小管内。将纳米颗粒分散在由1%羟乙基纤维素组成的水凝胶基质载体系统中，观察到该水凝胶系统在较长时间内具有增强的细菌抑制作用。含氯己定的纳米颗粒显示出作为根管手术药物载体的潜力。它们的大小和释放速率可以允许持续抑制根管系统中的细菌。
Root canal system disinfection is limited due to anatomical complexities. Better delivery systems of antimicrobial agents are needed to ensure efficient bacteria eradication. The purpose of this study was to design chlorhexidine-containing nanoparticles that could steadily release the drug. The drug chlorhexidine was encapsulated in poly(ethylene glycol)–block–poly(l-lactide) (PEG–b–PLA) to synthesize bilayer nanoparticles. The encapsulation efficiency was determined through thermogravimetric analysis (TGA), and particle characterization was performed through microscopy studies of particle morphology and size. Their antimicrobial effect was assessed over the endodontic pathogen Enterococcus faecalis. The nanoparticles ranged in size from 300–500 nm, which is considered small enough for penetration inside small dentin tubules. The nanoparticles were dispersed in a hydrogel matrix carrier system composed of 1% hydroxyethyl cellulose, and this hydrogel system was observed to have enhanced bacterial inhibition over longer periods of time. Chlorhexidine-containing nanoparticles demonstrate potential as a drug carrier for root canal procedures. Their size and rate of release may allow for sustained inhibition of bacteria in the root canal system.