Primary lateral sclerosis as progressive supranuclear palsy: Diagnosis by diffusion tensor imaging
Primary lateral sclerosis as progressive supranuclear palsy: Diagnosis by diffusion tensor imaging
复制标题
DOI：
10.1002/mds.24990
复制
发表时间：
2012-06-01
影响因子：
8.6
通讯作者：
Josephs, Keith A.
中科院分区：
文献类型：
--
作者：
Coon, Elizabeth A.;Whitwell, Jennifer L.;Josephs, Keith A.
背景：利用弥散张量成像评估白质束的完整性可以区分原发性侧索硬化和进行性核上性麻痹。方法：33名前瞻性招募的受试者进行标准化评估和弥散张量成像：3名原发性侧索硬化症患者表现为进行性核上麻痹的特征，10名可能或明确的进行性核上麻痹，20名匹配对照。我们比较了各组间皮质脊髓束、小脑上脚和胼胝体体的分数各向异性。结果：与对照组相比，原发性侧索硬化症和进行性核上麻痹患者的小脑上蒂和胼胝体体的各向异性分数均有所减少，但只有原发性侧索硬化症患者的皮质脊髓束有所减少。皮质脊髓束/小脑上脚的比值是诊断疾病的最佳指标（P < 0.02）。结论：皮质脊髓束/小脑上脚比值是区分原发性侧索硬化与进行性核上麻痹的标志。(c) 2012年运动障碍协会
Background: Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy. Methods: Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncles, and body of the corpus callosum between groups. Results: Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncle and body of the corpus callosum compared with controls, but only primary lateral sclerosis subjects showed reductions in the corticospinal tracts. A ratio of corticospinal tract/superior cerebellar peduncle best distinguished the disorders (P < .02). Conclusions: The corticospinal tract/superior cerebellar peduncle ratio is a marker to differentiate primary lateral sclerosis from progressive supranuclear palsy. (c) 2012 Movement Disorder Society