Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis
Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis
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循环可溶性 LR11（平滑肌细胞迁移的调节因子）水平与颈动脉狭窄患者的动脉粥样硬化斑块高度相关
DOI：
10.1016/j.cca.2018.12.005
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发表时间：
2019
期刊：
影响因子：
5
通讯作者：
Bujo H
中科院分区：
文献类型：
--
作者：
Harada M;Jiang M;Terai K;Ebinuma H;Hiruta N;Schneider WJ;Sugo N;Nagao T;Bujo H
背景：在无症状受试者中，从内膜SMCs释放的血浆sLR11水平与内膜厚度（IMT）呈正相关。我们已经评估了sLR11在颈动脉狭窄患者斑块状况中的病理意义，但尚不清楚。方法：采用解剖标本研究颈动脉斑块中LR11的存在。本文对46例患者进行了临床超声检查，以阐明sLR11与斑块状况的关系。结果：免疫组化显示增厚内膜内和颈动脉粥样硬化斑块中膜边界的SMCs中LR11水平较高。与健康对照组相比，患者体内的sLR11水平明显升高。单因素分析显示，sLR11与斑块评分呈显著正相关，并倾向于与狭窄分数相关。斑块评分的单因素和多元回归分析显示，sLR11、最大IMT和hdl -胆固醇独立决定斑块评分。最后，在随访1年后，对sLR11初始水平与影像学标志物变化的单因素分析显示，sLR11初始水平与狭窄分数进展显著相关。结论：在颈动脉粥样硬化斑块中大量表达的sLR11水平与斑块评分升高高度相关。sLR11水平可预测晚期颈动脉粥样硬化患者斑块状况。
Background: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intimamedia thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis. Methods: The presence of LR11 in carotid plaques was investigated using autopsy specimens. A clinical ultrasonography study for elucidating relationships between sLR11 and plaque condition was performed in 46 patients.Results: Immunohistochemistry showed high levels of LR11 in SMCs within thickened intima and at the mediaintima border of atherosclerotic carotid plaques. The levels of sLR11 in patients were clearly elevated compared to healthy controls. Univariate analysis of sLR11 revealed significant positive correlation with plaque score and a tendency to correlate with the stenotic fraction. Univariate and multiple regression analyses of plaque scores showed that sLR11, maximum IMT, and HDL-cholesterol independently determined plaque score. Finally, univariate analysis of initial sLR11 levels for changes in imaging markers after one-year follow-up showed that initial sLR11 levels significantly correlated with stenotic fraction progression. Conclusions: The levels of sLR11, abundantly expressed in carotid atherosclerotic plaques, are highly associated with increased plaque score. sLR11 levels may be predictive of plaque conditions in patients with advanced carotid atherosclerosis.