ELEVATION OF PLASMA VASOPRESSIN IN SPONTANEOUS MIGRAINE
ELEVATION OF PLASMA VASOPRESSIN IN SPONTANEOUS MIGRAINE
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DOI：
10.1046/j.1468-2982.1991.1106249.x
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发表时间：
1991-12-01
期刊：
影响因子：
4.9
通讯作者：
GRANT, PJ
中科院分区：
文献类型：
--
作者：
HAMPTON, KK;ESACK, A;GRANT, PJ
加压素是一种由垂体后叶分泌的血管活性激素。在低浓度下，它的作用是调节肾水排泄，但在较高浓度下，它具有许多肾外作用，包括对血流的影响。为了研究加压素在自发性偏头痛中的作用，从14名受试者（a）自发性偏头痛急性发作期间和（B）至少7天无头痛时收集配对样本。在发作期间，加压素持续升高（中位数（范围）3.5（1.2-9.6）pg/ml v0.5（0.5-1.1）pg/ml，p < 0.001）。最高的血管加压素浓度发生在唯一的病人谁呕吐。结果表明，在自发性偏头痛发作时，加压素升高，这可能部分与呕吐有关。在大多数情况下，加压素水平仅上升到足以产生一定的肾脏抗利尿作用，尽管在一些情况下，这些水平可能足以引起外周血流量的改变。加压素的释放可能与偏头痛中观察到的面部苍白和抗利尿有关。
Vasopressin is a vasoactive hormone secreted from the posterior pituitary. At low concentration its role is in regulating renal water excretion, but at higher concentrations it has a number of extrarenal actions, including effects on blood flow. To investigate the role of vasopressin in spontaneous migraine, paired samples were collected from 14 subjects (a) during an acute attack of spontaneous migraine, and (b) when symptom-free for at least seven days. During an attack, vasopressin was consistently raised (median (range) 3.5 (1.2-9.6) pg/ml v 0.5 (0.5-1.1) pg/ml, p < 0.001). The highest vasopressin concentration occurred in the only patient who vomited. The results suggest vasopressin rises during an attack of spontaneous migraine, and this may, in part, be related to emesis. In the majority, vasopressin levels only rose sufficiently to have some renal antidiuretic effect, although in some these levels could have been sufficient to cause alteration in peripheral blood flow. Release of vasopressin may be responsible for the facial pallor and antidiuresis observed in migraine.