Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children
Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children
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DOI：
10.1016/j.jpeds.2006.12.051
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发表时间：
2007-04-01
影响因子：
5.1
通讯作者：
Carrel, Aaron L.
中科院分区：
文献类型：
--
作者：
Allen, David B.;Nemeth, Blaise A.;Carrel, Aaron L.
目的：探讨超重中学生体脂（%BF）、心血管健康（CVF）和胰岛素抵抗（IR）之间的关系。研究设计：对106名中学生进行身体组成、最大耗氧量（Vo(2)）摄氧量/kg瘦体重（Vo(2)max/kgLBM）、空腹葡萄糖和胰岛素（FI）浓度及衍生稳态模型评估指数（HOMA(IR)）的评估。结果：%BF （r = 0.33, P < .001）和Vo(2)max/kgLBM （r = -0.42, P < .0001）与FI均有显著相关。双变量回归分析显示，%BF （P = 0.008 vs FI, P = 0.035 vs HOMA(IR)）和VO(2)max/kgLBM （P < 0.001 vs FI, P = 0.009 vs HOMA(IR)）是胰岛素敏感性的独立预测因子。在男性中，VO(2)max/kgLBM比%BF更能预测FI和HOMA（IR）。结论：在肥胖中学生中，%BF和VO(2)max/kgLBM是FI水平的独立预测因子。CVF和FI水平之间的关系在两性中都是显著的，但在男性中比%BF更深刻和更强。在日益肥胖的儿童人群中，降低2型糖尿病风险的努力应包括持续足够的运动干预，以改善CVF。
Objective: We studied the relationship between % body fat (%BF), cardiovascular fitness (CVF), and insulin resistance (IR) in overweight middle-school children.Study design: Middle school-children (n = 106, body mass index [BMI] > 95(th) percentile for age) underwent evaluation of body composition, maximal volume of oxygen utilization (Vo(2)) uptake/kg lean body mass (Vo(2)max/kgLBM), and fasting glucose and insulin (FI) concentrations and derived homeostasis model assessment index (HOMA(IR)).Results: Both %BF (r = .33, P < .001) and Vo(2)max/kgLBM (r = -0.42, P < .0001) were significantly correlated with FI. Bivariate regression analysis revealed %BF (P = .008 vs FI, P = .035 vs HOMA(IR)) and VO(2)max/kgLBM (P < .001 vs FI, P = .009 vs HOMA(IR)) to be independent predictors of insulin sensitivity. In males, VO(2)max/kgLBM was a better predictor of FI and HOMA(IR) than %BF.Conclusions: in obese middle-school children, both %BF and VO(2)max/kgLBM are independent predictors of FI levels. The relationship between CVF and FI levels was significant in both sexes but was particularly profound and stronger than %BF in males. Efforts to reduce risk of type 2 diabetes mellitus in an increasingly obese child population should include exercise intervention sustained enough to improve CVF.