Relationship between vascular calcification and bone mineral density in the old-order Amish
Relationship between vascular calcification and bone mineral density in the old-order Amish
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DOI：
10.1007/s00223-007-9006-4
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发表时间：
2007-04-01
影响因子：
4.2
通讯作者：
Mitchell, B. D.
中科院分区：
文献类型：
--
作者：
Shen, H.;Bielak, L. F.;Mitchell, B. D.
血管钙化和骨质疏松是常见的年龄相关过程，受遗传和非遗传因素的影响。这些过程的基础是否是共同的基因尚不清楚。我们测量了682名来自古老阿米什家族的男性和女性的冠状动脉钙化（CAC）、主动脉钙化（AC）和骨矿物质密度（BMD）。我们评估了这些性状的遗传力，然后使用方差分解程序评估性状的变异是否受到一组共同基因的影响（即，多效性）。股骨颈和脊柱BMD（0.65，0.63）和CAC和AC（0.43，0.42）检测到显着的遗传力。在两种性别中，CAC或AC的四分位数之间的平均BMD没有显著差异。无论是在总组还是任何一个亚组（男性、女性、绝经后女性）中，BMD和血管钙化之间的遗传或环境相关性都没有达到统计学显著性。然而，有心血管疾病（CVD）事件史的受试者股骨颈BMD显著低于无CVD既往史的受试者（年龄、性别、体重指数和家族结构校正P = 0.003）。我们没有发现共同基因影响骨和血管钙化联合分布的证据。然而，我们的研究结果确实揭示了在旧秩序阿米什人中有CVD病史的受试者的BMD较低。
Vascular calcification and osteoporosis are common age-related processes that are influenced by both genetic and nongenetic factors. Whether common genes underlie these processes is not known. We measured coronary artery calcification (CAC), aortic calcification (AC), and bone mineral density (BMD) in 682 men and women from large Old-Order Amish families. We assessed the heritabilities of these traits and then evaluated, using variance decomposition procedures, whether variation in the traits was influenced by a common set of genes (i.e., pleiotropy). Significant heritabilities were detected for BMD of the femoral neck and spine (0.65, 0.63) and CAC and AC (0.43, 0.42). Mean BMD did not differ significantly across quartiles of either CAC or AC in either sex. In neither the total group nor any single subgroup (men, women, postmenopausal women) did any of the genetic or environmental correlations between BMD and vascular calcification achieve statistical significance. However, subjects with a history of cardiovascular disease (CVD) events had significantly lower BMD at the femoral neck compared to subjects who reported no prior history of CVD (age-, sex-, body mass index-, and family structure-adjusted P = 0.003). We detected no evidence for shared genes affecting the joint distribution of bone and vascular calcification. However, our results do reveal a lower BMD in subjects with a prior history of CVD in the Old-Order Amish.