Effects of postmenopausal hypoestrogenism on skin collagen
Effects of postmenopausal hypoestrogenism on skin collagen
复制标题
DOI：
10.1016/s0378-5122(99)00077-8
复制
发表时间：
1999-12-15
期刊：
影响因子：
4.9
通讯作者：
Nappi, C
中科院分区：
文献类型：
--
作者：
Affinito, P;Palomba, S;Nappi, C
目的：探讨增龄和绝经后低雌激素对皮肤胶原蛋白含量的影响。方法：32例女性患者，年龄28~68岁，平均年龄48.78±9.86岁，绝经前14例，绝经后18例。用免疫组织化学和计算机图像分析技术检测I、III型胶原含量和III型/I型胶原比值，并与年龄和绝经年限相关。结果：绝经后妇女组与绝经后组比较，差异有统计学意义(P
Objective: The aim of our study was to evaluate the effect of aging and postmenopausal hypoestrogenism on skin collagen content. Methods: Thirty-two women (mean age 48.78+/-9.86; year+/-S.D., range 28-68), 14 in premenopause and 18 in postmenopause, underwent skin biopsies performed during laparotomic operation. The amount of collagen type I, III and type III/type I ratio was evaluated by immunohistochemistry and computerised image analysis, and was related to age and years of postmenopause. Results: In the postmenopausal patients, a significant (P