Redefining the serotonergic system by genetic lineage
Redefining the serotonergic system by genetic lineage
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DOI：
10.1038/nn2050
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发表时间：
2008-04-01
影响因子：
25
通讯作者：
Dymecki, Susan M.
中科院分区：
文献类型：
--
作者：
Jensen, Patricia;Farago, Anna F.;Dymecki, Susan M.
中枢产生降钙素的神经元在位置、形态、神经毒素敏感性和相关的临床病症方面是异质性的，但这种异质性的基础在很大程度上是未知的，区分降钙素能神经元的生理亚型的标记物也是未知的。在这里，我们重新定义的基础上，在祖细胞的差异制定的遗传程序的α-肾上腺素能亚型。我们发现了一个分子框架的α-肾上腺素能系统，具有遗传谱系作为其基础，很可能具有生理相关性，并将允许访问遗传定义的亚型进行操作。
Central serotonin-producing neurons are heterogeneous differing in location, morphology, neurotoxin sensitivity and associated clinical disorders - but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.