Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study.
Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study.
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DOI：
10.3389/fpsyt.2010.00134
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发表时间：
2010-01-01
影响因子：
4.7
通讯作者：
Nahas, Ziad
中科院分区：
文献类型：
--
作者：
Pincus, David;Kose, Samet;Nahas, Ziad
背景：催产素是一种减轻压力和亲社会的神经肽。到目前为止，没有研究催产素在调制抑郁症患者的大脑活动的影响，也没有试图将这种活动与其他人的精神活动的归因相关联。方法：我们招募了10名未服药的抑郁症成年人和10名匹配的健康对照，在交叉，双盲安慰剂对照fMRI 40 i.u.鼻内催产素研究（20 i.u.每公升）。每个受试者进行阅读的眼睛任务（RMET）之前和之后吸入催产素或安慰剂对照，共80 scans.Results：前催产素管理，RMET从事内侧和外侧前额叶皮层，杏仁核，杏仁核和联合区。抑郁的主题表现出增加前腹激活的RMET减去性别识别对比，而匹配的对照组表现出增加的背侧和额叶活动。与安慰剂相比，抑郁症受试者的催产素在上级额中回和前额叶的活动增加，而对照组在腹侧区域表现出更多的活动。催产素也导致了反向效应的反应时间归因任务组之间，控制越来越快，抑郁症的个人慢response.CONCLUSION：抑郁症是与增加大脑边缘活动的情绪心理归因的其他人，出现明显调制催产素相比，健康对照组。需要进一步的研究来探索长期暴露于亲社会神经肽对抑郁人群情绪的影响，并评估其临床意义。
BACKGROUND: Oxytocin is a stress-attenuating and pro-social neuropeptide. To date, no study has looked at the effects of oxytocin in modulating brain activity in depressed individuals nor attempted to correlate this activity with attribution of mental activity in others.METHOD: We enrolled 10 unmedicated depressed adults and 10 matched healthy controls in a crossover, double blind placebo controlled fMRI 40 i.u. intra-nasal oxytocin study (20 i.u. per nostril). Each subject performed reading the mind in the eyes task (RMET) before and after inhalation of oxytocin or placebo control for a total of 80 scans.RESULTS: Before oxytocin administration, RMET engaged the medial and lateral prefrontal cortex, amygdala, insula and associative areas. Depressed subjects showed increased anterior ventral activation for the RMET minus gender identification contrast whereas matched controls showed increased dorsal and frontal activity. Compared to placebo, oxytocin in depressed subjects showed increased activity in the superior middle frontal gyrus and insula, while controls exhibited more activity in ventral regions. Oxytocin also led to inverse effects in reaction times on attribution task between groups, with controls getting faster and depressed individuals slower to respond.CONCLUSION: Depression is associated with increased paralimbic activity during emotional mental attribution of others, appearing to be distinctly modulated by oxytocin when compared to healthy controls. Further studies are needed to explore long-term exposure to pro-social neuropeptides on mood in depressed populations and assess their clinical relevance.