Expression and function of phospholipase A2 in brain
Expression and function of phospholipase A2 in brain
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DOI：
10.1016/s0014-5793(02)03481-6
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发表时间：
2002-10-30
期刊：
影响因子：
3.5
通讯作者：
Dennis, EA
中科院分区：
文献类型：
--
作者：
Balboa, MA;Varela-Nieto, I;Dennis, EA
磷脂酶 A(2) (PLA(2)) 似乎在中枢神经系统细胞损伤中发挥着重要作用。我们研究了星形细胞瘤细胞系1231N1中PLA(2)的表达，发现表达了GIVA、GIVB、GIVC和GVI PLA(2)信息。 PLA(2) 活性会因炎症/损伤刺激（例如这些细胞中的白介素-1β 和脂多糖）而增加，但时间进程却截然不同。释放的花生四烯酸可能通过炎症刺激诱导的环氧合酶 2 转化为前列腺素 E-2。该细胞系统作为研究新 PLA(2) 形式 GIVB 和 GIVC 的损伤/炎症相关激活的模型。(C) 2002 年欧洲生化学会联合会。由 Elsevier Science B.V. 出版。保留所有权利。
Phospholipase A(2) (PLA(2)) appears to play a fundamental role in cell injury in the central nervous system. We have investigated PLA(2) expression in the astrocytoma cell line 1231N1, and found that GIVA, GIVB, GIVC and GVI PLA(2) messages are expressed. PLA(2) activity is increased by inflammatory/injury stimuli such as interleukin-1beta and lipopolysaccharide in these cells but with very different time courses. The arachidonic acid liberated is converted to prostaglandin E-2, possibly by cyclooxygenase-2, which is induced by inflammatory stimuli. This cell system emerges as a model to study injury/inflammation-related activation of the new PLA(2) forms GIVB and GIVC.(C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.