Homologue recognition during meiosis is associated with a change in chromatin conformation
Homologue recognition during meiosis is associated with a change in chromatin conformation
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DOI：
10.1038/ncb1168
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发表时间：
2004-09-01
影响因子：
21.3
通讯作者：
Moore, G
中科院分区：
文献类型：
--
作者：
Prieto, P;Shaw, P;Moore, G
在减数分裂过程中，同源染色体被分成两对，然后沿着它们的长度紧密排列或突触，同时在它们之间组装蛋白质结构，即联会复合体。然而，关于染色体如何首先识别彼此知之甚少（1）。在这里，我们表明，通过比较野生型小麦和小麦突变体的Ph1（同源染色体配对的抑制因子）的行为，当染色体识别一个合作伙伴配对时，在两个合作伙伴中触发了染色质的构象变化，随后是他们的亲密对齐。因此，在减数分裂开始时染色体的构象变化可以直接与识别相关。
During meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other(1). Here we show, by comparing the behaviour of wild-type wheat and wheat mutant for Ph1 (a suppressor of homologous chromosome pairing), that when chromosomes recognise a partner to pair with, a conformational change to the chromatin is triggered in both partners that is followed by their intimate alignment. Thus, a conformational change in the chromosomes at the onset of meiosis can be correlated directly with recognition.