Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate Virus-Like Particle Egress
Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate Virus-Like Particle Egress
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DOI：
10.1128/jvi.00470-13
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发表时间：
2013-07-01
影响因子：
5.4
通讯作者：
Harty, Ronald N.
中科院分区：
文献类型：
--
作者：
Lu, Jianhong;Qu, Yonggang;Harty, Ronald N.
我们已经鉴定出宿主IQGAP 1作为埃博拉病毒（EBOV）VP40的相互作用伴侣，并且其表达是EBOV VP40病毒样颗粒（VLP）出芽所需的。IQGAP 1在细胞迁移和丝状伪足形成过程中参与肌动蛋白细胞骨架重塑。EBOV VP40 VLP出口链接病毒中IQGAP 1的物理相互作用和功能要求出芽到细胞骨架重塑机器。因此，这种相互作用代表了开发阻断丝状病毒出芽和传播的治疗剂的新靶标。
We have identified host IQGAP1 as an interacting partner for Ebola virus (EBOV) VP40, and its expression is required for EBOV VP40 virus-like particle (VLP) budding. IQGAP1 is involved in actin cytoskeletal remodeling during cell migration and formation of filopodia. The physical interaction and the functional requirement for IQGAP1 in EBOV VP40 VLP egress link virus budding to the cytoskeletal remodeling machinery. Consequently, this interaction represents a novel target for development of therapeutics to block budding and transmission of filoviruses.