Cows milk-dependent exercise-induced anaphylaxis under the condition of a premenstrual or ovulatory phase following skin sensitization.
Cows milk-dependent exercise-induced anaphylaxis under the condition of a premenstrual or ovulatory phase following skin sensitization.
复制标题
DOI：
10.2332/allergolint.c-08-62
复制
发表时间：
2008-12-01
期刊：
影响因子：
--
通讯作者：
Nishigori, Chikako
中科院分区：
文献类型：
--
作者：
Bito, Toshinori;Kanda, Eriko;Nishigori, Chikako
背景技术背景：一名24岁的女性异位性皮炎偶尔出现症状，包括呼吸困难和全身性荨麻疹后，摄入的食物含有牛奶。类似的事件一直在继续，并已治疗经验，因为年龄的16 years.CASE SUMMARY：虽然皮肤试验和IgE RAST显示阳性反应的牛奶，激发试验与牛奶单独没有引起任何症状。因此，怀疑为食物依赖性运动诱导的过敏反应（FDEIA），但使用牛奶、阿司匹林和运动的各种组合进行的检查未能引起任何症状。最后，在排卵期用牛奶进行激发试验，然后服用阿司匹林和运动，引起全身性荨麻疹、呼吸困难和低血压。讨论：当她用含有牛奶作为主要成分的浴盐洗澡一年时，牛奶的症状开始了15岁。从该病史可以看出，通过湿疹皮肤对牛奶致敏。在这种情况下，经前或排卵期的激素变化也是FDEA发展的重要因素。
BACKGROUND: A 24 year-old woman with atopic dermatitis occasionally developed symptoms, including dyspnea and generalized urticaria, following ingestion of food containing cows milk. Similar episodes had continued, and had been treated empirically since the age of 16 years.CASE SUMMARY: Although a skin test and IgE RAST showed positive reactions to cows milk, a provocation test with cows milk alone did not induce any symptoms. Therefore, food-dependent exercise-induced anaphylaxis (FDEIA) was suspected, but examination using various combinations of cows milk, aspirin and exercise failed to elicit any symptoms. Finally, a provocation test during the ovulatory phase with cows milk followed by aspirin and exercise evoked systemic urticaria, dyspnea and hypotension.DISCUSSION: The symptoms against cows milk began when she took baths with bath salts containing cows milk as its main ingredient for one year at the age 15 years. Sensitization to cows milk through eczematous skin is indicated from this history. Hormonal change during a premenstrual or ovulatory phase is also an important factor for the development of FDEIA in this case.