miRNAs associated with prostate cancer risk and progression.
miRNAs associated with prostate cancer risk and progression.
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DOI：
10.1186/s12894-017-0206-6
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发表时间：
2017-03-20
期刊：
影响因子：
2
通讯作者：
Di Pietro G
中科院分区：
文献类型：
--
作者：
Luu HN;Lin HY;Sørensen KD;Ogunwobi OO;Kumar N;Chornokur G;Phelan C;Jones D;Kidd L;Batra J;Yamoah K;Berglund A;Rounbehler RJ;Yang M;Lee SH;Kang N;Kim SJ;Park JY;Di Pietro G
前列腺癌是美国男性中最常见的恶性肿瘤。虽然前列腺癌的诊断在过去十年中取得了相当大的进步，但预测疾病结果仍然是一个主要的临床挑战。最近的前列腺癌表达谱研究表明，microRNAs （miRNAs）可能作为前列腺癌风险和疾病进展的潜在生物标志物。mirna包括一个大约22个核苷酸长的非蛋白编码rna的大家族，通过转录后调控基因表达并参与许多细胞过程的调控。在这篇综述中，我们讨论了miRNA在评估前列腺癌疾病进展的研究中的现状。讨论重点强调了先前研究的关键发现，这些研究报道了miRNA在前列腺癌风险和进展中的作用，提供了对miRNA对前列腺癌影响的理解。我们的综述表明，这些研究和一些前列腺癌相关mirna的报道之间存在一些一致的结果。目前有希望的候选基因是miR-1、- 21、106b、141、- 145、- 205、- 221和- 375，它们是研究最频繁的，似乎对前列腺癌的诊断和预后最有希望。然而，先前的研究结果表明，mirna可能作为有前景的生物标志物在前列腺癌的风险和进展中发挥重要作用。
Prostate cancer is the most common malignancy among men in the US. Though considerable improvement in the diagnosis of prostate cancer has been achieved in the past decade, predicting disease outcome remains a major clinical challenge. Recent expression profiling studies in prostate cancer suggest microRNAs (miRNAs) may serve as potential biomarkers for prostate cancer risk and disease progression. miRNAs comprise a large family of about 22-nucleotide-long non-protein coding RNAs, regulate gene expression post-transcriptionally and participate in the regulation of numerous cellular processes. In this review, we discuss the current status of miRNA in studies evaluating the disease progression of prostate cancer. The discussion highlights key findings from previous studies, which reported the role of miRNAs in risk and progression of prostate cancer, providing an understanding of the influence of miRNA on prostate cancer. Our review indicates that somewhat consistent results exist between these studies and reports on several prostate cancer related miRNAs. Present promising candidates are miR-1, −21, 106b, 141, −145, −205, −221, and −375, which are the most frequently studied and seem to be the most promising for diagnosis and prognosis for prostate cancer. Nevertheless, the findings from previous studies suggest miRNAs may play an important role in the risk and progression of prostate cancer as promising biomarkers.