BETA-ARRESTIN - A PROTEIN THAT REGULATES BETA-ADRENERGIC-RECEPTOR FUNCTION
BETA-ARRESTIN - A PROTEIN THAT REGULATES BETA-ADRENERGIC-RECEPTOR FUNCTION
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DOI：
10.1126/science.2163110
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发表时间：
1990-06-22
期刊：
影响因子：
56.9
通讯作者：
LEFKOWITZ, RJ
中科院分区：
文献类型：
--
作者：
LOHSE, MJ;BENOVIC, JL;LEFKOWITZ, RJ
β-受体激动剂或受体激动剂特异性脱敏肾上腺素能受体被认为是由一种特定的激酶β-肾上腺素能受体激酶（β方舟）。然而，最近的数据表明，这种激酶需要一个辅因子来抑制受体功能。这种辅因子的互补DNA被克隆，并发现编码与视网膜蛋白抑制蛋白同源的418个氨基酸的蛋白质。蛋白质，称为β-表达并部分纯化arrestin。它抑制β ARK-磷酸化β-的信号传导功能肾上腺素能受体超过75%，但不是视紫红质。建议β-与β方舟协同作用的抑制蛋白对β-肾上腺素能受体
Homologous or agonist-specific desensitization of .beta.-adrenergic receptors is thought to be mediated by a specific kinase, the .beta.-adrenergic receptor kinase (.beta.ARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such a cofactor was cloned and found to encode a 418-amino acid protein homologous to the retinal protein arrestin. The protein, termed .beta.-arrestin, was expressed and partially purified. It inhibited the signaling function of .beta.ARK-phosphorylated .beta.-adrenergic receptors by more than 75 percent, but not that of rhodopsin. It is proposed that .beta.-arrestin in concert with .beta.ARK effects homologous desensitization of .beta.-adrenergic receptors.