The Haemostatic Balance – Astrup Revisited
The Haemostatic Balance – Astrup Revisited
复制标题
止血平衡——Astrup 重温
DOI：
10.1159/000022461
复制
发表时间：
1999
影响因子：
--
通讯作者：
C. Whitton
中科院分区：
文献类型：
--
作者：
P. Gaffney;T. Edgell;C. Whitton
Tage Astrup教授首先阐述了血液流动性的概念，即血液流动性涉及血液凝块倾向和这种凝块溶解之间的平衡。当时，这种止血平衡似乎涉及这样一种概念，即纤维蛋白的形成通过刺激纤维蛋白溶解活性来协调其自身的破坏。在这篇评论中，我们已经澄清了这种平衡的细节，并发展了论文，Astrup的远见的平衡概念涉及到各种控制机制。这些涉及凝血酶，乍一看是促凝血剂，也可以与血栓调节蛋白结合，通过产生活化蛋白C作为抗凝活性的刺激物。凝血酶可激活的纤维蛋白溶解抑制剂（TAFI）也参与这种平衡，因为凝血酶的产生通过TAFI途径引起纤维蛋白溶解的中和。激肽释放酶/因子XII/尿激酶途径进行了讨论，表明凝血和纤维蛋白溶解的产生之间的平衡的另一个方面。除了对止血平衡的各个方面的深入了解外，本综述的总体主题是，当组织受损时，血液具有很强的凝块倾向，完整的血管系统需要主要的抗凝系统来防止凝块粘附并稳定在血管系统中。
Prof. Tage Astrup first elaborated the notion that blood fluidity involved a balance between the tendency of blood to clot and for such clots to lyse. It would seem that, at that time, this haemostatic balance involved the notion that forming fibrin orchestrated its own destruction by stimulating fibrinolytic activity. In this review, we have clarified the detail of this balance and developed the thesis that Astrup’s far-sighted balance notions involve a variety of control mechanisms. These involve the notion that thrombin, being at first sight a procoagulant, can also, in conjunction with thrombomodulin, act as a stimulus of anticoagulant activity by the generation of activated protein C. The thrombin-activatable fibrinolytic inhibitor (TAFI) is also involved in this balance since the generation of thrombin provokes the neutralisation of fibrinolysis by the TAFI pathway. The kallikrein/factor XII/urokinase pathway is discussed indicating yet another aspect of balance between the generation of coagulation and fibrinolysis. The overall theme of this review, apart from an insight into various aspects of the haemostatic balance, is that blood has a strong tendency to clot when tissue is damaged, and the intact vasculature requires major anticoagulant systems to prevent clots adhering to and stabilising in the vasculature.
DOI：
10.1016/s0021-9258(19)68276-1
发表时间：
1982-01
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
N. Esmon;W. Owen;C. Esmon
通讯作者：
N. Esmon;W. Owen;C. Esmon
蛋白 C 依赖性血栓溶解机制：纤溶酶原激活剂抑制剂的作用。
影响因子：
20.3
作者：
Sakata,Y;Loskutoff,DJ;Gladson,CL;Hekman,CM;Griffin,JH
通讯作者：
Griffin,JH
组织纤溶酶原激活剂与培养的人内皮细胞的结合。
DOI：
10.1172/jci113262
发表时间：
1987
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Hajjar,KA;Hamel,NM;Harpel,PC;Nachman,RL
通讯作者：
Nachman,RL