Monochorionic Dizygous Twins Presenting With Blood Chimerism and Discordant Sex
Monochorionic Dizygous Twins Presenting With Blood Chimerism and Discordant Sex
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DOI：
10.1017/thg.2013.41
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发表时间：
2013-08-01
影响因子：
0.9
通讯作者：
Claahsen-van der Grinten, Hedi L.
中科院分区：
文献类型：
--
作者：
Smeets, Dominique;van Vugt, John M. G.;Claahsen-van der Grinten, Hedi L.
单绒毛膜双卵双胞胎可能比以前认为的更常见，因为许多情况下仍然无法识别，特别是当孩子有相同的性别。在这里，我们提出了一对双卵，性别不一致的单绒毛膜双胞胎谁是人工授精后受孕。对胎盘的组织学检查和对健康男孩和女孩的广泛遗传学研究清楚地证明，他们确实是血液循环完全连接的单绒毛膜双胞胎。我们的结论是，当咨询父母期待单绒毛膜双胞胎的不和谐的性别，不仅在双胞胎之一的性分化障碍应予以解决，但也有可能与一个完全正常的（性）发育的两个孩子的双卵性。
Monochorionic dizygous twins are probably more frequent than considered previously as many cases remain unrecognized, especially when the children have the same sex. Here we present a pair of dizygous, sex-discordant monochorionic twins who were conceived after artificial insemination. Histological examination of the placenta and extensive genetic studies of the healthy boy and girl clearly proved that they indeed were monochorionic dizygous twins with a fully joined blood circulation. We conclude that when counseling parents expecting monochorionic twins of discordant sex, not only a disorder of sexual differentiation in one of the twins should be addressed but also the possibility of dizygosity with a completely normal (sexual) development of both children.