Differential effect of functional ablation of thalamic reticular nucleus on the acquisition of passive and active avoidance.
Differential effect of functional ablation of thalamic reticular nucleus on the acquisition of passive and active avoidance.
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DOI：
10.3109/00207459308987213
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发表时间：
1993-11-01
期刊：
影响因子：
--
通讯作者：
Bures, J
中科院分区：
文献类型：
--
作者：
Bucherelli, C;Tassoni, G;Bures, J
本研究探讨了丘脑网状核损伤对基底核大细胞损伤所致记忆障碍的可能作用。慢性气管插管大鼠在获得被动回避（PAR）-主动回避（AAR）联合任务前60 min（PRE）或后2 min（POST），将3 ng河豚毒素（TTX）注入网状核。三天后检索测试期间，在同一（IPSI）或在对侧（CONTRA）半球的网状核的单侧TTX封锁。网状核的单侧失活既不影响PAR的获取也不影响PAR的检索，但在PRE条件下干扰AAR的获取。在PRE-CONTRA组中AAR再获取受损，但在其他组中未受损。网状核阻断（AAR中断而无PAR损伤）的效果与NBM损伤后AAR易化和PAR中断形成对比。它的结论是，NBM损害的后果并没有增强无意的丘脑侵犯。
The possible contribution of inadvertent damage of the thalamic reticular nucleus to memory impairment caused by lesion of nucleus basalis magnocellularis (NBM) was examined. Rats carrying chronically implanted cannulae received unilateral injection of 3 ng tetrodotoxin (TTX) into the reticular nucleus either 60 min before (PRE) or 2 min after (POST) acquisition of a combined passive avoidance (PAR)--active avoidance (AAR) task. Three days later retrieval was tested during unilateral TTX blockade of the reticular nucleus in the same (IPSI) or in the opposite (CONTRA) hemisphere. Unilateral inactivation of the reticular nucleus affected neither acquisition nor retrieval of PAR, but interfered with AAR acquisition under the PRE conditions. AAR reacquisition was impaired in the PRE-CONTRA but not in the other groups. The effects of reticular nucleus blockade (AAR disruption without PAR impairment) contrast with AAR facilitation and PAR disruption after NBM lesions. It is concluded that the consequences of NBM damage are not enhanced by unintentional thalamic encroachment.