Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review

Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review
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MCC950 抑制 NLRP3 炎症小体激活的靶点:文献综述

DOI:
10.1007/s10753-019-01098-8
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发表时间:
2019-10
期刊:
影响因子:
5.1
通讯作者:
Bin Yu
Bin Yu
中科院分区:
医学2区
文献类型:
--
作者:
Danbin Wu;Yefei Chen;Yingxin Sun;Qing Gao;Huhu Li;Zhengfei Yang;Yangxue Wang;Xijuan Jiang;Bin Yu

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MCC950已被认为是一种选择性阻断NLRP3炎性小体激活的特异性小分子抑制剂。然而,其确切的作用机制仍不明确。积累研究表明,依赖氯离子外流的ASC S
MCC950 has been proposed as a specific small molecule inhibitor that can selectively block NLRP3 inflammasome activation. However, the exact mechanism of its action is still ambiguous. Accumulating investigations imply that chloride efflux–dependent ASC s
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