Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex
Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex
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DOI：
10.1016/j.neuroscience.2004.03.038
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发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
McEwen, BS
中科院分区：
文献类型：
--
作者：
Nacher, J;Pham, K;McEwen, BS
应激和应激相关激素诱导成年中枢神经系统神经元的结构变化。海马、杏仁核和前额皮质的神经元在慢性应激后经历神经突起重塑。在海马中，这些效应中的一些可以通过长期给予肾上腺类固醇来模仿。神经元结构的这些变化可能由某些与可塑性事件相关的分子介导，例如神经细胞粘附分子的聚唾液酸化形式（PSA-NCAM）。PSA-NCAM在成年海马中的表达持续存在，并且在慢性应激后上调。梨状皮质在成年期也显示出相当水平的PSA-NCAM，间接证据表明它也可能是压力和压力相关激素的目标。使用免疫组织化学，我们研究了表达的PSA-NCAM和doublecortin（DCX;另一种蛋白质牵连神经元结构可塑性）在梨状皮质的成年大鼠进行了21天的慢性束缚应激或口服皮质酮管理在同一时期。我们的研究结果表明，慢性应激和慢性皮质酮给药对PSA-NCAM和DCX的表达有不同的影响。虽然慢性应激增加的PSA-NCAM-和DCX-免疫反应细胞在梨状皮质层II的数量，慢性皮质酮管理减少这些数字。这些发现表明，压力和肾上腺类固醇影响梨状皮质，并表明在这个区域，在海马，他们可能会引起结构变化。这是一种潜在的机制，通过这种机制，压力和皮质酮调节边缘区的功能，如参与嗅觉记忆。(C)2004年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Stress and stress-related hormones induce structural changes in neurons of the adult CNS. Neurons in the hippocampus, the amygdala and the prefrontal cortex undergo neurite remodeling after chronic stress. In the hippocampus some of these effects can be mimicked with chronic administration of adrenal steroids. These changes in neuronal structure may be mediated by certain molecules related to plastic events such as the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). The expression of PSA-NCAM persists in the adult hippocampus and it is up-regulated after chronic stress. The piriform cortex also displays considerable levels of PSA-NCAM during adulthood and indirect evidence suggests that it may also be the target of stress and stress related-hormones. Using immunohistochemistry we have studied the expression of PSA-NCAM and doublecortin (DCX; another protein implicated in neuronal structural plasticity) in the piriform cortex of adult rats subjected either to 21 days of chronic restraint stress or to oral corticosterone administration during the same period. Our results indicate that chronic stress and chronic corticosterone administration have differential effects on the expression of PSA-NCAM and DCX. While chronic stress increases the number of PSA-NCAM- and DCX-immunoreactive cells in the piriform cortex layer II, chronic corticosterone administration decreases these numbers. These findings indicate that stress and adrenal steroids affect the piriform cortex and suggest that in this region, as in the hippocampus, they may induce structural changes. This is a potential mechanism by which stress and corticosterone modulate functions of this limbic region, such as its participation in olfactory memory. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.