Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications.
Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications.
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DOI：
10.2147/ijn.s321984
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发表时间：
2021
影响因子：
8
通讯作者：
Tang M
中科院分区：
文献类型：
--
作者：
Wei H;Hu Y;Wang J;Gao X;Qian X;Tang M
超顺磁性氧化铁纳米粒子（SPION）由于其优异的超顺磁性和可靠的可追溯性，在生物医学领域得到了广泛的研究和应用。但随着核组成、壳类型和转染剂的优化，不同SPION的细胞毒性和代谢有很大差异，标记细胞也表现出不同的细胞行为。因此，需要对SPION的构建和应用进行全面的回顾。本文综述了近年来SPION在生物医学领域的研究进展。在总结了SPION的毒性后，讨论了SPION在体外的摄取、分布和代谢。然后概述了标记细胞行为的调控。最后，提出了SPION优化过程中面临的主要挑战，并展望了SPION的未来发展。
Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated and applied in the field of biomedicine due to their excellent superparamagnetic properties and reliable traceability. However, with the optimization of core composition, shell types and transfection agents, the cytotoxicity and metabolism of different SPIONs have great differences, and the labeled cells also show different cellular behaviors. Therefore, a holistic review of the construction and application of SPIONs is desired. This review focuses the advances of SPIONs in the field of biomedicine in recent years. After summarizing the toxicity of different SPIONs, the uptake, distribution and metabolism of SPIONs in vitro were discussed. Then, the regulation of labeled-cells behavior is outlined. Furthermore, the major challenges in the optimization process of SPIONs and insights on its future developments are proposed.