βIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer
βIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer
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DOI：
10.1016/j.humpath.2016.11.005
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发表时间：
2017-03-01
期刊：
影响因子：
3.3
通讯作者：
Jacobsen, Frank
中科院分区：
文献类型：
--
作者：
Hinsch, Andrea;Chaker, Aref;Jacobsen, Frank
遗传不稳定性的发展是肿瘤进展的标志。III型/3-微管蛋白（TUBB 3）是参与染色体分离的微管的组分。它的过度表达与膀胱癌的不良特征有关。为了研究TUBB 3在遗传不稳定性发展中的作用，我们比较了TUBB 3表达与组织病理学特征和遗传不稳定性和肿瘤侵袭性的替代标志物; HER 2，TOP 2A，CCND 1，RAF 1和FGFRI的拷贝数变化; p53的核积聚，以及700多例膀胱癌组织微阵列（TMA）中的细胞增殖。TUBB 3表达与高级别和晚期癌症相关（P
Development of genetic instability is a hallmark of tumor progression. Type III /3-tubulin (TUBB3) is a component of microtubules involved in chromosome segregation. Its overexpression has been linked to adverse features of urinary bladder cancer. To investigate the role of TUBB3 for development of genetic instability, we compared TUBB3 expression with histopathological features and surrogate markers of genetic instability and tumor aggressiveness; copy number changes of HER2, TOP2A, CCND1, RAF1, and FGFRI; nuclear accumulation of p53, and cell proliferation in a tissue micro array (TMA) with more than 700 bladder cancers. TUBB3 expression was linked to high-grade and advanced -stage cancers (P