Time course of apoptosis in lacrimal gland after rabbit ovariectomy.
Time course of apoptosis in lacrimal gland after rabbit ovariectomy.
复制标题
兔卵巢切除术后泪腺细胞凋亡的时程。
DOI：
10.1007/978-1-4615-5359-5_73
复制
发表时间：
1998
影响因子：
--
通讯作者：
Warren,DW
中科院分区：
文献类型：
--
作者：
Azzarolo,AM;Wood,RL;Mircheff,AK;Olsen,E;Huang,ZM;Zolfagari,R;Warren,DW
泪液分泌不足是干眼症最常见的原因。干眼症通过从不适和接触透镜不耐受到持续疼痛和烧灼感以及潜在的威胁视力的角膜损伤的症状大大降低生活质量。干眼症的发病率，无论起源[原发性泪液缺乏症（PLD）或干燥综合征]是性别相关的，影响女性比男性更频繁。PLD发生尤其频繁绝经后和怀孕期间，哺乳期，口服避孕药的使用，表明激素因素在调节泪腺功能中发挥重要作用。女性干燥综合征的发病率较高，表明激素因素也会影响影响泪腺的自身免疫现象的发病率和进展。最近对这一概念进行了审查。
Lacrimal insufficiency is the most frequent cause of dry eye conditions. Dry eye greatly decreases the quality of life through symptoms ranging from discomfort and contact lens intolerance to persistent pain and burning sensation and potential vision-threatening corneal damage. The incidence of dry eye, regardless of origin [primary lacrimal deficiency (PLD) or Sjögren s syndrome] is gender-related, affecting women much more frequently than men. PLD occurs especially frequently after menopause and during pregnancy, lactation, and oral contraceptive use, suggesting that hormonal factors play an important role in regulating lacrimal gland function. The greater incidence of Sjögren’s syndrome in women indicates that hormonal factors also influence the incidence and progression of autoimmune phenomena that affect the lacrimal glands. This concept has been recently reviewed.1