The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle
The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle
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DOI：
10.1016/s0021-9150(98)00251-2
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发表时间：
1999-02-01
期刊：
影响因子：
5.3
通讯作者：
Rull, JA
中科院分区：
文献类型：
--
作者：
Aguilar, CA;Talavera, G;Rull, JA
载脂蛋白E4等位基因在工业化国家与LDL胆固醇浓度升高和心血管风险增加相关。本研究的目的是评估APOE基因位点的遗传变异对美国土著农村人群血脂谱的影响。我们检查了142名健康随机选择的成年人生活在墨西哥西部的土著社区的血脂水平和常见的载脂蛋白E等位基因。他们的年龄为38 +/- 17岁，BMI为25.7 +/- 4.5 kg/m2。血浆胆固醇、甘油三酯、LDL C和HDL C分别为165 +/- 29.6、126 +/- 83、98 +/- 26和42 +/- 12.7 mg/dl。91%的受试者的Lp（a）浓度低于20 mg/dl，30%的受试者的Lp（a）浓度低于2 mg/dl。最常见的APOE基因型为E3/3（63%），其次为E3/4（39.1%）。E2等位基因的患病率很低（2.3%）。在E3/E3和E3/E4受试者之间未观察到LDL C浓度差异，但是E2/3基因型携带者的LDL C水平较低。胆固醇和载脂蛋白B水平获得了相似的结果。总之，在以前的研究中与E4等位基因相关的LDL C水平升高在非西化习惯的人群中没有观察到。环境因素，如饮食和生活方式，可能超过了载脂蛋白E4等位基因的存在所导致的高胆固醇血症倾向。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
The apolipoprotein E4 allele is associated in industrialized countries with an elevated LDL cholesterol concentration and an increased cardiovascular risk. Our purpose in this study was to assess the influence of the genetic variation at the APOE gene locus on the lipid profile of a Native American rural population. We examined plasma lipid levels and the common apo E alleles in 142 healthy randomly selected adults living in their native communities in western Mexico. Their age was 38 +/- 17 years and the BMI 25.7 +/- 4.5 kg/m(2). Plasma cholesterol, triglycerides, LDL C and HDL C were 165 +/- 29.6, 126 +/- 83, 98 +/- 26 and 42 +/- 12.7 mg/dl respectively. Ninety-one per cent of the subjects had Lp(a) concentrations below 20 mg/dl and 30% had levels lower than 2 mg/dl. The most common APOE genotype was E3/3 (63%), followed by E3/4 (39.1%). The prevalence of the E2 allele was very low (2.3%). No difference was observed in LDL C concentrations between the E3/E3 and E3/E4 subjects, however carriers of the E2/3 genotype had lower LDL C levels. Similar results were obtained for cholesterol and apo B levels. In summary, the increased LDL C levels associated with the E4 allele in previous studies were not observed in a population with non-westernized habits. Environmental factors, such as diet and lifestyle, could outweigh the hypercholesterolemic predisposition resulting from the presence of the apo E4 allele. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.