Coronary collateral development during chronic ischemia: serial assessment using harmonic myocardial contrast echocardiography.
Coronary collateral development during chronic ischemia: serial assessment using harmonic myocardial contrast echocardiography.
复制标题
慢性缺血期间的冠状动脉侧支发育：使用谐波心肌造影超声心动图进行连续评估。
DOI：
10.1016/s0735-1097(00)00739-7
复制
发表时间：
2000
影响因子：
24
通讯作者：
Villanueva,FS
中科院分区：
文献类型：
--
作者：
Mills,JD;Fischer,D;Villanueva,FS
OBJECTIVESWe sought to characterize collateral development in an experimental model of chronic myocardial ischemia by using myocardial contrast echocardiography (MCE).BACKGROUNDCoronary collaterals maintain myocyte viability during myocardial ischemia. The natural history and determinants of collateral development are difficult to study serially in vivo.METHODSThe left anterior descending coronary artery (LAD) in nine dogs was encircled (day 0) with a hydraulic occluder and ameroid constrictor to enable reversible and gradual total LAD occlusion, respectively. Myocardial contrast echocardiography was performed using intravenous injection of perfluorocarbon gas-containing microbubbles during two-dimensional harmonic echocardiographic imaging. Myocardial contrast echocardiography images and radiolabeled microsphere flow measurements were obtained during transient LAD occlusion on day 0. Over the ensuing six weeks, MCE imaging was performed during LAD occlusion at 10-day intervals.RESULTSMyocardial contrast echocardiography risk area size (expressed as a percent of the left ventricular short axis slice) decreased over the course of six weeks (32% ± 3% on day 0, 21% ± 3% at day 10, 5 ± 3% at day 20, 1% ± 1% at day 30 and 1% ± 1% at day 42, p ≤ 0.001 vs. day 0). Radiolabeled microsphere-derived LAD flow, normalized to left circumflex flow, correspondingly increased between day 0 and day 42 (0.14 ± 0.02 to 0.90 ± 0.07, p < 0.02).CONCLUSIONSCollateral development occurs relatively early and rapidly in this chronic canine model. Myocardial contrast echocardiography using harmonic imaging and intravenous injection of microbubbles can uniquely track the spatial and temporal course of collateral growth, and may be a powerful tool for noninvasively mapping the efficacy of therapeutic angiogenic strategies in vivo.
