INTERACTIONS OF PATTERN-GENERATING INTERNEURONS CONTROLLING FEEDING IN LYMNAEA-STAGNALIS
INTERACTIONS OF PATTERN-GENERATING INTERNEURONS CONTROLLING FEEDING IN LYMNAEA-STAGNALIS
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DOI：
10.1152/jn.1985.54.6.1396
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发表时间：
1985-12-01
影响因子：
2.5
通讯作者：
BENJAMIN, PR
中科院分区：
文献类型：
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作者：
ELLIOTT, CJH;BENJAMIN, PR
细胞内的记录是从节律产生的中间神经元在Armenaea喂养系统。摄食模式是一个三相节律的神经元间活动（N1，N2，N3）相应的protraction，rasp，和吞咽。我们描述的发射模式和解剖的前运动中间神经元，其中每个火灾的主要突发只有一个阶段的喂养节奏。节律可以由N1细胞的稳定去极化驱动。节律的相位通过短暂刺激N2或N3中间神经元而重置。N1神经元兴奋N2中间神经元，而这些中间神经元反过来抑制N1细胞。这种反复出现的抑制途径可以解释从N1期到N2期的转换。N2中间神经元的内源性特性显然是N2爆发终止的原因。N3中间神经元显示抑制后反弹（PIR），这可能有助于他们的爆发结束后的N2抑制输入。N2和N3中间神经元抑制N1细胞。当N3爆发消失时，N1细胞在去极化电流的刺激下恢复活动。中间神经元之间的相互作用主要是通过离散的，单相突触后电位，遵循1：1。它们具有相对较短的延迟（2-12 ms）和持续时间（高达100 ms）。三种类型的前运动中间神经元之间的突触连接足以解释进食过程中所见的活动顺序。
Intracellular recordings were made from rhythm-generating interneurons in the Lymnaea feeding system. The feeding pattern is a three-phase rhythm of interneuronal activity (N1, N2, N3) corresponding to protraction, rasp, and swallow. We describe the firing pattern and anatomy of the premotor interneurons, each of which fires a predominant burst in only one phase of the feeding rhythm. The rhythm can be driven by steady depolarization of N1 cells. The phase of the rhythm is reset by brief stimulation of N2 or N3 interneurons. N1 neurons excite the N2 interneurons, and these in turn inhibit the N1 cells. This recurrent inhibitory pathway can account for the switch from the N1 phase of the feeding cycles to the N2 phase. The endogenous properties of the N2 interneurons are apparently responsible for the termination of N2 bursts. N3 interneurons display postinhibitory rebound (PIR), and this probably contributes to their burst after the end of the N2 inhibitory input. N2 and N3 interneurons inhibit the N1 cells. When the N3 burst dies away, activity in N1 cells resumes under the stimulus of depolarizing current. Interactions between interneurons are mainly by discrete, monophasic postsynaptic potentials, that follow 1:1. They have relatively short latency (2-12 ms) and duration (up to 100 ms). The synaptic connections between the three types of premotor interneurons are sufficient to account for the sequence of activity seen during feeding.