Peripheral levels of BDNF and NGF in primary headaches
Peripheral levels of BDNF and NGF in primary headaches
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DOI：
10.1111/j.1468-2982.2005.01006.x
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发表时间：
2006-02-01
期刊：
影响因子：
4.9
通讯作者：
Leon, A
中科院分区：
文献类型：
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作者：
Blandini, F;Rinaldi, L;Leon, A
神经营养因子，如脑源性神经营养因子(BDNF)和神经生长因子(NGF)，与疼痛的产生和调节有关。为了研究是否可以检测到患有伤害性疾病(如原发性头痛)的受试者的神经营养素水平的变化，我们测定了偏头痛患者、有或没有先兆或丛集性头痛(CH)患者发作间期和健康志愿者外周血(血小板和血浆)BDNF和NGF的水平。所有被研究的原发性头痛患者的血小板脑源性神经营养因子水平均显著降低(偏头痛与对照组相比P<；0.001；偏头痛组与对照组相比P<；0.001)，而偏头痛患者与对照组相比血小板神经生长因子水平有选择性地降低(偏头痛与对照组相比P<；0.001)。这些变化并不伴随着神经营养素血浆水平的显著变化。我们的发现首次显示不同类型的原发性头痛患者外周神经营养因子(BDNF和NGF)水平的变化，提示BDNF和NGF可能参与了这些疾病的病理生理过程，并增加了外周神经营养因子的差异可能有助于从生物学上区分偏头痛和CH的可能性。
Neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), have been implicated in the generation and modulation of pain. To investigate whether alterations in neurotrophin levels can be detected in subjects suffering from nociceptive disorders, such as primary headaches, we determined the peripheral (platelet and plasma) levels of BDNF and NGF in patients suffering from migraine, with or without aura, or cluster headache (CH), in the interictal phase, and in healthy volunteers. All primary headaches patients studied showed significantly decreased platelet levels of BDNF (migraine vs. controls P < 0.001; CH vs. controls P < 0.01), while a selective reduction of platelet NGF was observed in migraine sufferers and not in CH patients compared with control subjects (migraine vs. controls P < 0.001). These changes were not accompanied by significant modifications of neurotrophin plasma levels. Our findings show for the first time that changes in peripheral levels of neurotrophines (BDNF and NGF) occur in patients suffering from different types of primary headaches, suggesting a potential involvement of BDNF and NGF in the pathophysiology of these disorders, and raising the possibility that differences in peripheral neurotrophins may help to distinguish migraine biologically from CH.