Subtype-dependent Morphological and Functional Degeneration of Retinal Ganglion Cells in Mouse Models of Experimental Glaucoma.
Subtype-dependent Morphological and Functional Degeneration of Retinal Ganglion Cells in Mouse Models of Experimental Glaucoma.
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发表时间：
2015-05
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通讯作者：
Puyang Zhen;Hui Chen;Xiaorong Liu
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作者：
Puyang Zhen;Hui Chen;Xiaorong Liu
在这篇简短的综述中，Puyang和她的同事比较了三个实验室在实验性青光眼小鼠模型中视网膜神经节细胞（RGC）树突和功能变性的结果[1-4]。在小鼠中诱导急性或慢性高眼压，并应用不同的技术来鉴定RGC类型。采用多电极阵列（MEA）记录方法观察视网膜节细胞（RGCs）的光反应特性。这些研究支持了实验性青光眼中RGCs的形态和功能退化具有亚型依赖性的观点。
In this short review, Puyang and her colleagues compared the results from three laboratories on the dendritic and functional degeneration of retinal ganglion cells (RGCs) in mouse models of experimental glaucoma [1-4]. Acute or chronic ocular hypertension was induced in mice, and different techniques were applied to identify RGC types. The dendritic alternations of RGCs were examined following the induction of ocular hypertension, and their light response properties were characterized by the multi-electrode array (MEA) recording. These studies support the notion that the morphological and functional degeneration of RGCs are subtype-dependent in experimental glaucoma.