Conformational states of Leu5- and Met5-enkephalins in solution.
Conformational states of Leu5- and Met5-enkephalins in solution.
复制标题
溶液中 Leu5- 和 Met5- 脑啡肽的构象状态。
DOI：
10.1016/0006-291x(85)90288-8
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发表时间：
1985
影响因子：
3.1
通讯作者：
R. Bhatnagar
中科院分区：
文献类型：
--
作者：
V. Renugopalakrishnan;R. Rapaka;T. Collette;L. A. Carreira;R. Bhatnagar
用红外光谱和激光拉曼光谱研究了亮氨酸5-和蛋氨酸5-脑啡肽在水溶液和DMSO溶液中的分子构象。通过傅立叶自去卷积谱带分析了Leu 5-和Met 5-脑啡肽在水溶液中的FT-IR光谱中的酰胺I，II和III区域。发现Leu 5-脑啡肽在水溶液中以II型β-转角和β-折叠结构存在，而Met 5-脑啡肽在水溶液中形成β-转角结构的倾向较小。这些脑啡肽的不同构象可能与不同的受体类型结合。
The molecular conformations of Leu5- and Met5-enkephalins in aqueous and DMSO solutions were investigated by FT-IR and laser Raman spectroscopic methods. The amide I, II, and III regions in the FT-IR spectra of Leu5- and Met5-enkephalins in aqueous solution were analyzed by performing Fourier self-deconvolution of the bands. Leu5-enkephalin in aqueous solution is found to exist in both type II β-turn and β-sheet structures, whereas Met5-enkephalin has a lesser tendency to form β-turn structure in aqueous solution. It is likely that these different conformers of enkephalins might bind to different receptor types.
构象受限的环状脑啡肽类似物，具有显着的 δ 阿片受体激动剂选择性。
影响因子：
6.1
作者：
Mosberg,HI;Hurst,R;Hruby,VJ;Galligan,JJ;Burks,TF;Gee,K;Yamamura,HI
通讯作者：
Yamamura,HI