Prolonged parent-child separation and pain in adolescence: The role of HPA-axis genetic variations
Prolonged parent-child separation and pain in adolescence: The role of HPA-axis genetic variations
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长期亲子分离和青春期疼痛：HPA 轴遗传变异的作用
DOI：
10.1016/j.jad.2021.05.092
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Chen XX;Xu LP;Zeng CC;Zhang XY;Tao FB;Sun Y
越来越多的证据表明，儿童期的逆境是疼痛的预测因子，下丘脑-垂体-肾上腺（HPA）轴的遗传变异与疼痛风险相关。本研究采用中国安徽省阜阳市农村地区219名青少年为研究对象，探讨儿童期与父母分离时间延长和HPA多基因风险评分（PRS）对中国农村青少年疼痛的可能影响。通过访谈收集亲子分离情况，并使用11点数字评定量表报告疼痛强度。使用改进的多重连接检测反应（iMLDR）技术进行SNP基因分型。根据2个基因的3个单核苷酸多态性（SNPs）计算PRS（FKBP 5和NR 3C 1）与HPA轴应激反应有关。与没有父母分离的青少年相比，与父母分离的青少年的疼痛评分更高，但是，这种关联仅在PRS组的中到高三分位数的青少年中观察到（中度组亲子分离vs中度组无亲子分离：3.07 vs 1.57，P < 0.001;最高组亲子分离vs最高组无亲子分离：3.02 vs. 1.26，P < 0.001;最低组亲子分离与最低组无亲子分离：2.34 vs. 1.25，P = 0.225）。在控制了人口学特征、精神病理症状、不良童年经历、父母温暖、长时间的童年亲子分离后，中度和高度PRS组的疼痛评分分别增加了1.52分（95%CI：0.72，2.33）和1.72分（95%CI：1.13，2.31）。
Increasing evidence has demonstrated that childhood adversity was a predictor of pain and hypothalamic-pituitary-adrenal (HPA) axis genetic variation is associated with pain risk. This study aims to explore possible effects of prolonged childhood separation from parents and HPA polygenic risk score (PRS) on pain among adolescents in rural China.We used data from 219 adolescents in rural area of Fuyang city, Anhui province, China. Parent-child separation was collected through interview and pain intensity was reported using the 11-point Numerical Rating Scale. SNP genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique. The PRS was computed based on 3 single nucleotide polymorphisms (SNPs) in 2 genes (FKBP5 and NR3C1) related to HPA-axis stress reactivity.Pain among adolescents separated from both parents scored higher compared to those without parent-child separation, however, this association was only observed in adolescents with moderate to high tertiles of PRS groups (parent-child separation in moderate group vs. no parent-child separation in moderate group: 3.07 vs. 1.57, P < 0.001; parent-child separation in highest group vs. no parent-child separation in highest group: 3.02 vs. 1.26, P < 0.001; parent-child separation in lowest group vs. no parent-child separation in lowest group: 2.34 vs. 1.25, P = 0.225). After controlled for demographic characteristics, psychopathological symptoms, adverse childhood experiences, parental warmth, prolonged childhood parent-child separation increased pain scores by 1.52 points (95% CI:0.72, 2.33) and 1.72 points (95% CI:1.13, 2.31) in moderate and high PRS groups, respectively.Our findings suggest that adolescents separated from both parents while carrying more risk alleles related to HPA-axis stress reactivity are at heightened risk of pain.